Overview of Research Development on the Role of NF-κB Signaling in Mastitis

SIMPLE SUMMARY: NF-κB signaling has been widely studied for its role in inflammatory and immunity-related diseases. Mastitis is considered one of the inflammatory and immunity associated diseases which are a serious threat to the global dairy industry. Having such a critical role in immunity and inflammation, NF-κB signaling is currently under target for therapeutic purposes in mastitis control research. The virulent factor, lipopolysaccharides (LPS), of bacteria after attachment with relevant Toll-like receptors (TLRs) on mammary epithelial cells starts its pathogenesis by using NF-κB signaling to cause mastitis. Several studies have proved that the blocking of NF-κB signaling could be a useful strategy for mastitis control. ABSTRACT: Mastitis is the inflammation of the mammary gland. Escherichia coli and Staphylococcus aureus are the most common bacteria responsible for mastitis. When mammary epithelial cells are infected by microorganisms, this activates an inflammatory response. The bacterial infection is recognized by innate pattern recognition receptors (PRRs) in the mammary epithelial cells, with the help of Toll-like receptors (TLRs). Upon activation by lipopolysaccharides, a virulent agent of bacteria, the TLRs further trigger nuclear factor-κB (NF-κB) signaling to accelerate its pathogenesis. The NF-κB has an essential role in many biological processes, such as cell survival, immune response, inflammation and development. Therefore, the NF-κB signaling triggered by the TLRs then regulates the transcriptional expression of specific inflammatory mediators to initiate inflammation of the mammary epithelial cells. Thus, any aberrant regulation of NF-κB signaling may lead to many inflammatory diseases, including mastitis. Hence, the inhibiting of NF-κB signaling has potential therapeutic applications in mastitis control strategies. In this review, we highlighted the regulation and function of NF-κB signaling in mastitis. Furthermore, the role of NF-κB signaling for therapeutic purposes in mastitis control has been explored in the current review.