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Prospects and Challenges of Translational Corneal Bioprinting
Corneal transplantation remains the ultimate treatment option for advanced stromal and endothelial disorders. Corneal tissue engineering has gained increasing interest in recent years, as it can bypass many complications of conventional corneal transplantation. The human cornea is an ideal organ for...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7552635/ https://www.ncbi.nlm.nih.gov/pubmed/32640721 http://dx.doi.org/10.3390/bioengineering7030071 |
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author | Fuest, Matthias Yam, Gary Hin-Fai Mehta, Jodhbir S. Duarte Campos, Daniela F. |
author_facet | Fuest, Matthias Yam, Gary Hin-Fai Mehta, Jodhbir S. Duarte Campos, Daniela F. |
author_sort | Fuest, Matthias |
collection | PubMed |
description | Corneal transplantation remains the ultimate treatment option for advanced stromal and endothelial disorders. Corneal tissue engineering has gained increasing interest in recent years, as it can bypass many complications of conventional corneal transplantation. The human cornea is an ideal organ for tissue engineering, as it is avascular and immune-privileged. Mimicking the complex mechanical properties, the surface curvature, and stromal cytoarchitecure of the in vivo corneal tissue remains a great challenge for tissue engineering approaches. For this reason, automated biofabrication strategies, such as bioprinting, may offer additional spatial control during the manufacturing process to generate full-thickness cell-laden 3D corneal constructs. In this review, we discuss recent advances in bioprinting and biomaterials used for in vitro and ex vivo corneal tissue engineering, corneal cell-biomaterial interactions after bioprinting, and future directions of corneal bioprinting aiming at engineering a full-thickness human cornea in the lab. |
format | Online Article Text |
id | pubmed-7552635 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75526352020-10-14 Prospects and Challenges of Translational Corneal Bioprinting Fuest, Matthias Yam, Gary Hin-Fai Mehta, Jodhbir S. Duarte Campos, Daniela F. Bioengineering (Basel) Review Corneal transplantation remains the ultimate treatment option for advanced stromal and endothelial disorders. Corneal tissue engineering has gained increasing interest in recent years, as it can bypass many complications of conventional corneal transplantation. The human cornea is an ideal organ for tissue engineering, as it is avascular and immune-privileged. Mimicking the complex mechanical properties, the surface curvature, and stromal cytoarchitecure of the in vivo corneal tissue remains a great challenge for tissue engineering approaches. For this reason, automated biofabrication strategies, such as bioprinting, may offer additional spatial control during the manufacturing process to generate full-thickness cell-laden 3D corneal constructs. In this review, we discuss recent advances in bioprinting and biomaterials used for in vitro and ex vivo corneal tissue engineering, corneal cell-biomaterial interactions after bioprinting, and future directions of corneal bioprinting aiming at engineering a full-thickness human cornea in the lab. MDPI 2020-07-06 /pmc/articles/PMC7552635/ /pubmed/32640721 http://dx.doi.org/10.3390/bioengineering7030071 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Fuest, Matthias Yam, Gary Hin-Fai Mehta, Jodhbir S. Duarte Campos, Daniela F. Prospects and Challenges of Translational Corneal Bioprinting |
title | Prospects and Challenges of Translational Corneal Bioprinting |
title_full | Prospects and Challenges of Translational Corneal Bioprinting |
title_fullStr | Prospects and Challenges of Translational Corneal Bioprinting |
title_full_unstemmed | Prospects and Challenges of Translational Corneal Bioprinting |
title_short | Prospects and Challenges of Translational Corneal Bioprinting |
title_sort | prospects and challenges of translational corneal bioprinting |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7552635/ https://www.ncbi.nlm.nih.gov/pubmed/32640721 http://dx.doi.org/10.3390/bioengineering7030071 |
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