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Comparison of Blood Pressure and Kidney Markers between Adolescent Former Preterm Infants and Term Controls

Background: Preterm infants are at an increased risk of developing hypertension and chronic kidney disease later in life. No recommendations exist for blood pressure (BP) and renal follow up for these patients. Aim: To compare BP and serum and urinary kidney markers between preterm-born adolescents...

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Autores principales: Staub, Eveline, Urfer-Maurer, Natalie, Lemola, Sakari, Risch, Lorenz, Evers, Katrina S., Welzel, Tatjana, Pfister, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7552693/
https://www.ncbi.nlm.nih.gov/pubmed/32957564
http://dx.doi.org/10.3390/children7090141
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author Staub, Eveline
Urfer-Maurer, Natalie
Lemola, Sakari
Risch, Lorenz
Evers, Katrina S.
Welzel, Tatjana
Pfister, Marc
author_facet Staub, Eveline
Urfer-Maurer, Natalie
Lemola, Sakari
Risch, Lorenz
Evers, Katrina S.
Welzel, Tatjana
Pfister, Marc
author_sort Staub, Eveline
collection PubMed
description Background: Preterm infants are at an increased risk of developing hypertension and chronic kidney disease later in life. No recommendations exist for blood pressure (BP) and renal follow up for these patients. Aim: To compare BP and serum and urinary kidney markers between preterm-born adolescents and term-born controls. Methods: BP measurements in 51 preterm-born (≤32 weeks gestational age) and 82 term-born adolescents at the age of 10–15 years were conducted. Stepwise regression analysis explored the association between BP and participant characteristics. Kidney markers measured in the serum and urine were creatinine, neutrophil gelatinase-associated lipocalin (NGAL), and uromodulin. Kidney markers measured in the serum were cystatin C, beta-2 microglobulin, and beta trace protein. Results: Systolic BP was significantly higher in preterm boys compared with term boys, but not in girls, and low birth weight was associated with higher BP in boys. In the preterm group, maternal hypertension/preeclampsia and adolescent height were associated with higher systolic BP. Serum creatinine and NGAL were significantly higher in the preterm group. Conclusions: Our study confirms an inverse sex-dependant relationship between birth weight and BP at adolescent age. The higher serum creatinine and NGAL in the preterm group may indicate that premature birth affects kidney function in the long term.
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spelling pubmed-75526932020-10-19 Comparison of Blood Pressure and Kidney Markers between Adolescent Former Preterm Infants and Term Controls Staub, Eveline Urfer-Maurer, Natalie Lemola, Sakari Risch, Lorenz Evers, Katrina S. Welzel, Tatjana Pfister, Marc Children (Basel) Article Background: Preterm infants are at an increased risk of developing hypertension and chronic kidney disease later in life. No recommendations exist for blood pressure (BP) and renal follow up for these patients. Aim: To compare BP and serum and urinary kidney markers between preterm-born adolescents and term-born controls. Methods: BP measurements in 51 preterm-born (≤32 weeks gestational age) and 82 term-born adolescents at the age of 10–15 years were conducted. Stepwise regression analysis explored the association between BP and participant characteristics. Kidney markers measured in the serum and urine were creatinine, neutrophil gelatinase-associated lipocalin (NGAL), and uromodulin. Kidney markers measured in the serum were cystatin C, beta-2 microglobulin, and beta trace protein. Results: Systolic BP was significantly higher in preterm boys compared with term boys, but not in girls, and low birth weight was associated with higher BP in boys. In the preterm group, maternal hypertension/preeclampsia and adolescent height were associated with higher systolic BP. Serum creatinine and NGAL were significantly higher in the preterm group. Conclusions: Our study confirms an inverse sex-dependant relationship between birth weight and BP at adolescent age. The higher serum creatinine and NGAL in the preterm group may indicate that premature birth affects kidney function in the long term. MDPI 2020-09-17 /pmc/articles/PMC7552693/ /pubmed/32957564 http://dx.doi.org/10.3390/children7090141 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Staub, Eveline
Urfer-Maurer, Natalie
Lemola, Sakari
Risch, Lorenz
Evers, Katrina S.
Welzel, Tatjana
Pfister, Marc
Comparison of Blood Pressure and Kidney Markers between Adolescent Former Preterm Infants and Term Controls
title Comparison of Blood Pressure and Kidney Markers between Adolescent Former Preterm Infants and Term Controls
title_full Comparison of Blood Pressure and Kidney Markers between Adolescent Former Preterm Infants and Term Controls
title_fullStr Comparison of Blood Pressure and Kidney Markers between Adolescent Former Preterm Infants and Term Controls
title_full_unstemmed Comparison of Blood Pressure and Kidney Markers between Adolescent Former Preterm Infants and Term Controls
title_short Comparison of Blood Pressure and Kidney Markers between Adolescent Former Preterm Infants and Term Controls
title_sort comparison of blood pressure and kidney markers between adolescent former preterm infants and term controls
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7552693/
https://www.ncbi.nlm.nih.gov/pubmed/32957564
http://dx.doi.org/10.3390/children7090141
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