Dynamics of genomic and immune responses during primary immunotherapy resistance in mismatch repair–deficient tumors

Mismatch repair–deficient (dMMR) cancers generate a substantial number of immunogenic neoantigens, rendering them sensitive to immunotherapy. Yet, there is considerable variability in responses, and roughly one-half of dMMR cancers are refractory to immunotherapy. Here we study a patient with dMMR l...

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Detalles Bibliográficos
Autores principales: Takahashi, Nobuyuki, Rajapakse, Vinodh N., Pongor, Lorinc, Kumar, Suresh, Tlemsani, Camille, Erwin-Cohen, Rebecca, Young, Howard A., Hewitt, Stephen, Wei, Jun S., Khan, Javed, Villarino, Alejandro V., Trepel, Jane B., Thomas, Anish
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2020
Materias:
Research Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7552928/
https://www.ncbi.nlm.nih.gov/pubmed/33028646
http://dx.doi.org/10.1101/mcs.a005678

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