Du laboratoire à l’usage clinique : le défi de la production de plaquettes in vitro()

Platelet transfusions, which are currently totally dependent on altruistic donations, are absolutely necessary to the treatment of patients with thrombocytopenia following trauma, surgery or other pathologies (especially malignancies). Producing platelets in vitro represent a major technological and...

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Detalles Bibliográficos
Autores principales: Bouet, G., Mookerjee, S., Foster, H., Waller, A., Ghevaert, C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Published by Elsevier Masson SAS on behalf of l'Académie nationale de médecine. 2020
Materias:
Revue Générale
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7553122/
https://www.ncbi.nlm.nih.gov/pubmed/33078026
http://dx.doi.org/10.1016/j.banm.2020.10.004
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author Bouet, G.
Mookerjee, S.
Foster, H.
Waller, A.
Ghevaert, C.
author_facet Bouet, G.
Mookerjee, S.
Foster, H.
Waller, A.
Ghevaert, C.
author_sort Bouet, G.
collection PubMed
description Platelet transfusions, which are currently totally dependent on altruistic donations, are absolutely necessary to the treatment of patients with thrombocytopenia following trauma, surgery or other pathologies (especially malignancies). Producing platelets in vitro represent a major technological and scientific breathrough that would address logistical issues (supply chain, stock holding…) and medical concerns (compatibility and biosafety). The translation of this innovation will need to be accompanied by rigorous quality control, harmonised between laboratory when it comes to functionality and biosafety for use in the clinic.
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spelling pubmed-75531222020-10-13 Du laboratoire à l’usage clinique : le défi de la production de plaquettes in vitro() Bouet, G. Mookerjee, S. Foster, H. Waller, A. Ghevaert, C. Bull Acad Natl Med Revue Générale Platelet transfusions, which are currently totally dependent on altruistic donations, are absolutely necessary to the treatment of patients with thrombocytopenia following trauma, surgery or other pathologies (especially malignancies). Producing platelets in vitro represent a major technological and scientific breathrough that would address logistical issues (supply chain, stock holding…) and medical concerns (compatibility and biosafety). The translation of this innovation will need to be accompanied by rigorous quality control, harmonised between laboratory when it comes to functionality and biosafety for use in the clinic. Published by Elsevier Masson SAS on behalf of l'Académie nationale de médecine. 2020-12 2020-10-13 /pmc/articles/PMC7553122/ /pubmed/33078026 http://dx.doi.org/10.1016/j.banm.2020.10.004 Text en © 2020 Published by Elsevier Masson SAS on behalf of l'Académie nationale de médecine. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Revue Générale
Bouet, G.
Mookerjee, S.
Foster, H.
Waller, A.
Ghevaert, C.
Du laboratoire à l’usage clinique : le défi de la production de plaquettes in vitro()
title Du laboratoire à l’usage clinique : le défi de la production de plaquettes in vitro()
title_full Du laboratoire à l’usage clinique : le défi de la production de plaquettes in vitro()
title_fullStr Du laboratoire à l’usage clinique : le défi de la production de plaquettes in vitro()
title_full_unstemmed Du laboratoire à l’usage clinique : le défi de la production de plaquettes in vitro()
title_short Du laboratoire à l’usage clinique : le défi de la production de plaquettes in vitro()
title_sort du laboratoire à l’usage clinique : le défi de la production de plaquettes in vitro()
topic Revue Générale
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7553122/
https://www.ncbi.nlm.nih.gov/pubmed/33078026
http://dx.doi.org/10.1016/j.banm.2020.10.004
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