Continuous flexibility analysis of SARS-CoV-2 spike prefusion structures

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Using a new consensus-based image-processing approach together with principal component analysis, the flexibility and conformational dynamics of the SARS-CoV-2 spike in the prefusion state have been analysed. These studies revealed concerted motions involving the receptor-binding domain (RBD), N-ter...

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Detalles Bibliográficos
Autores principales: Melero, Roberto, Sorzano, Carlos Oscar S., Foster, Brent, Vilas, José-Luis, Martínez, Marta, Marabini, Roberto, Ramírez-Aportela, Erney, Sanchez-Garcia, Ruben, Herreros, David, del Caño, Laura, Losana, Patricia, Fonseca-Reyna, Yunior C., Conesa, Pablo, Wrapp, Daniel, Chacon, Pablo, McLellan, Jason S., Tagare, Hemant D., Carazo, Jose-Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2020
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7553147/
https://www.ncbi.nlm.nih.gov/pubmed/33063791
http://dx.doi.org/10.1107/S2052252520012725
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