Clofazimine is a broad-spectrum coronavirus inhibitor that antagonizes SARS-CoV-2 replication in primary human cell culture and hamsters

COVID-19 pandemic is the third zoonotic coronavirus (CoV) outbreak of the century after severe acute respiratory syndrome (SARS) in 2003 and Middle East respiratory syndrome (MERS) since 2012. Treatment options for CoVs are largely lacking. Here, we show that clofazimine, an anti-leprosy drug with a...

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Detalles Bibliográficos
Autores principales: Yuan, Shuofeng, Yin, Xin, Meng, XiangZhi, Chan, Jasper, Ye, Zi-Wei, Riva, Laura, Pache, Lars, Chan, Chris Chun-Yiu, Lai, Pok-Man, Chan, Chris, Poon, Vincent, Matsunaga, Naoko, Pu, Yuan, Yuen, Chun-Kit, Cao, Jianli, Liang, Ronghui, Tang, Kaiming, Sheng, Li, Du, Yushen, Xu, Wan, Sze, Kong-Hung, Zhang, Jinxia, Chu, Hin, Kok, Kin-Hang, To, Kelvin, Jin, Dong-Yan, Sun, Ren, Chanda, Sumit, Yuen, Kwok-Yung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Journal Experts 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7553155/
https://www.ncbi.nlm.nih.gov/pubmed/33052331
http://dx.doi.org/10.21203/rs.3.rs-86169/v1

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