CD8+ T cell responses in convalescent COVID-19 individuals target epitopes from the entire SARS-CoV-2 proteome and show kinetics of early differentiation

Characterization of the T cell response in individuals who recover from SARS-CoV-2 infection is critical to understanding its contribution to protective immunity. A multiplexed peptide-MHC tetramer approach was used to screen 408 SARS-CoV-2 candidate epitopes for CD8+ T cell recognition in a cross-s...

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Detalles Bibliográficos
Autores principales: Kared, Hassen, Redd, Andrew D, Bloch, Evan M, Bonny, Tania S., Sumatoh, Hermi, Kairi, Faris, Carbajo, Daniel, Abel, Brian, Newell, Evan W, Bettinotti, Maria P., Benner, Sarah E., Patel, Eshan U., Littlefield, Kirsten, Laeyendecker, Oliver, Shoham, Shmuel, Sullivan, David, Casadevall, Arturo, Pekosz, Andrew, Nardin, Alessandra, Fehlings, Michael, Tobian, Aaron AR, Quinn, Thomas C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7553170/
https://www.ncbi.nlm.nih.gov/pubmed/33052343
http://dx.doi.org/10.1101/2020.10.08.330688

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