Fatty acid oxidation of alternatively activated macrophages prevents foam cell formation, but Mycobacterium tuberculosis counteracts this process via HIF-1α activation

The ability of Mycobacterium tuberculosis (Mtb) to persist inside host cells relies on metabolic adaptation, like the accumulation of lipid bodies (LBs) in the so-called foamy macrophages (FM), which are favorable to Mtb. The activation state of macrophages is tightly associated to different metabol...

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Detalles Bibliográficos
Autores principales: Genoula, Melanie, Marín Franco, José Luis, Maio, Mariano, Dolotowicz, Belén, Ferreyra, Malena, Milillo, M. Ayelén, Mascarau, Rémi, Moraña, Eduardo José, Palmero, Domingo, Matteo, Mario, Fuentes, Federico, López, Beatriz, Barrionuevo, Paula, Neyrolles, Olivier, Cougoule, Céline, Lugo-Villarino, Geanncarlo, Vérollet, Christel, Sasiain, María del Carmen, Balboa, Luciana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7553279/
https://www.ncbi.nlm.nih.gov/pubmed/33002063
http://dx.doi.org/10.1371/journal.ppat.1008929

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