Aldh inhibitor restores auditory function in a mouse model of human deafness

Genetic hearing loss is a common health problem with no effective therapy currently available. DFNA15, caused by mutations of the transcription factor POU4F3, is one of the most common forms of autosomal dominant non-syndromic deafness. In this study, we established a novel mouse model of the human...

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Detalles Bibliográficos
Autores principales: Zhu, Guang-Jie, Gong, Sihao, Ma, Deng-Bin, Tao, Tao, He, Wei-Qi, Zhang, Linqing, Wang, Fang, Qian, Xiao-Yun, Zhou, Han, Fan, Chi, Wang, Pei, Chen, Xin, Zhao, Wei, Sun, Jie, Chen, Huaqun, Wang, Ye, Gao, Xiang, Zuo, Jian, Zhu, Min-Sheng, Gao, Xia, Wan, Guoqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7553308/
https://www.ncbi.nlm.nih.gov/pubmed/32970669
http://dx.doi.org/10.1371/journal.pgen.1009040

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