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Complex relationships between Aedes vectors, socio-economics and dengue transmission—Lessons learned from a case-control study in northeastern Thailand

BACKGROUND/OBJECTIVES: Dengue fever is an important public health concern in most tropical and subtropical countries, and its prevention and control rest on vector surveillance and control. However, many aspects of dengue epidemiology remain unclear; in particular, the relationship between Aedes vec...

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Autores principales: Fustec, Benedicte, Phanitchat, Thipruethai, Hoq, Mohammad Injamul, Aromseree, Sirinart, Pientong, Chamsai, Thaewnongiew, Kesorn, Ekalaksananan, Tipaya, Bangs, Michael J., Corbel, Vincent, Alexander, Neal, Overgaard, Hans J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7553337/
https://www.ncbi.nlm.nih.gov/pubmed/33001972
http://dx.doi.org/10.1371/journal.pntd.0008703
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author Fustec, Benedicte
Phanitchat, Thipruethai
Hoq, Mohammad Injamul
Aromseree, Sirinart
Pientong, Chamsai
Thaewnongiew, Kesorn
Ekalaksananan, Tipaya
Bangs, Michael J.
Corbel, Vincent
Alexander, Neal
Overgaard, Hans J.
author_facet Fustec, Benedicte
Phanitchat, Thipruethai
Hoq, Mohammad Injamul
Aromseree, Sirinart
Pientong, Chamsai
Thaewnongiew, Kesorn
Ekalaksananan, Tipaya
Bangs, Michael J.
Corbel, Vincent
Alexander, Neal
Overgaard, Hans J.
author_sort Fustec, Benedicte
collection PubMed
description BACKGROUND/OBJECTIVES: Dengue fever is an important public health concern in most tropical and subtropical countries, and its prevention and control rest on vector surveillance and control. However, many aspects of dengue epidemiology remain unclear; in particular, the relationship between Aedes vector abundance and dengue transmission risk. This study aims to identify entomological and immunological indices capable of discriminating between dengue case and control (non-case) houses, based on the assessment of candidate indices, as well as individual and household characteristics, as potential risk factors for acquiring dengue infection. METHODS: This prospective, hospital-based, case-control study was conducted in northeastern Thailand between June 2016 and August 2019. Immature and adult stage Aedes were collected at the houses of case and control patients, recruited from district hospitals, and at patients’ neighboring houses. Blood samples were tested by RDT and PCR to detect dengue cases, and were processed with the Nterm-34 kDa salivary peptide to measure the human immune response to Aedes bites. Socioeconomic status, and other individual and household characteristics were analyzed as potential risk factors for dengue. RESULTS: Study findings showed complex relationships between entomological indices and dengue risk. The presence of DENV-infected Aedes at the patient house was associated with 4.2-fold higher odds of dengue. On the other hand, Aedes presence (irrespective of infectious status) in the patient’s house was negatively associated with dengue. In addition, the human immune response to Aedes bites, was higher in control than in case patients and Aedes adult abundance and immature indices were higher in control than in case houses at the household and the neighboring level. Multivariable analysis showed that children aged 10–14 years old and those aged 15–25 years old had respectively 4.5-fold and 2.9-fold higher odds of dengue infection than those older than 25 years. CONCLUSION: DENV infection in female Aedes at the house level was positively associated with dengue infection, while adult Aedes presence in the household was negatively associated. This study highlights the potential benefit of monitoring dengue viruses in Aedes vectors. Our findings suggest that monitoring the presence of DENV-infected Aedes mosquitoes could be a better indicator of dengue risk than the traditional immature entomological indices.
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spelling pubmed-75533372020-10-21 Complex relationships between Aedes vectors, socio-economics and dengue transmission—Lessons learned from a case-control study in northeastern Thailand Fustec, Benedicte Phanitchat, Thipruethai Hoq, Mohammad Injamul Aromseree, Sirinart Pientong, Chamsai Thaewnongiew, Kesorn Ekalaksananan, Tipaya Bangs, Michael J. Corbel, Vincent Alexander, Neal Overgaard, Hans J. PLoS Negl Trop Dis Research Article BACKGROUND/OBJECTIVES: Dengue fever is an important public health concern in most tropical and subtropical countries, and its prevention and control rest on vector surveillance and control. However, many aspects of dengue epidemiology remain unclear; in particular, the relationship between Aedes vector abundance and dengue transmission risk. This study aims to identify entomological and immunological indices capable of discriminating between dengue case and control (non-case) houses, based on the assessment of candidate indices, as well as individual and household characteristics, as potential risk factors for acquiring dengue infection. METHODS: This prospective, hospital-based, case-control study was conducted in northeastern Thailand between June 2016 and August 2019. Immature and adult stage Aedes were collected at the houses of case and control patients, recruited from district hospitals, and at patients’ neighboring houses. Blood samples were tested by RDT and PCR to detect dengue cases, and were processed with the Nterm-34 kDa salivary peptide to measure the human immune response to Aedes bites. Socioeconomic status, and other individual and household characteristics were analyzed as potential risk factors for dengue. RESULTS: Study findings showed complex relationships between entomological indices and dengue risk. The presence of DENV-infected Aedes at the patient house was associated with 4.2-fold higher odds of dengue. On the other hand, Aedes presence (irrespective of infectious status) in the patient’s house was negatively associated with dengue. In addition, the human immune response to Aedes bites, was higher in control than in case patients and Aedes adult abundance and immature indices were higher in control than in case houses at the household and the neighboring level. Multivariable analysis showed that children aged 10–14 years old and those aged 15–25 years old had respectively 4.5-fold and 2.9-fold higher odds of dengue infection than those older than 25 years. CONCLUSION: DENV infection in female Aedes at the house level was positively associated with dengue infection, while adult Aedes presence in the household was negatively associated. This study highlights the potential benefit of monitoring dengue viruses in Aedes vectors. Our findings suggest that monitoring the presence of DENV-infected Aedes mosquitoes could be a better indicator of dengue risk than the traditional immature entomological indices. Public Library of Science 2020-10-01 /pmc/articles/PMC7553337/ /pubmed/33001972 http://dx.doi.org/10.1371/journal.pntd.0008703 Text en © 2020 Fustec et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Fustec, Benedicte
Phanitchat, Thipruethai
Hoq, Mohammad Injamul
Aromseree, Sirinart
Pientong, Chamsai
Thaewnongiew, Kesorn
Ekalaksananan, Tipaya
Bangs, Michael J.
Corbel, Vincent
Alexander, Neal
Overgaard, Hans J.
Complex relationships between Aedes vectors, socio-economics and dengue transmission—Lessons learned from a case-control study in northeastern Thailand
title Complex relationships between Aedes vectors, socio-economics and dengue transmission—Lessons learned from a case-control study in northeastern Thailand
title_full Complex relationships between Aedes vectors, socio-economics and dengue transmission—Lessons learned from a case-control study in northeastern Thailand
title_fullStr Complex relationships between Aedes vectors, socio-economics and dengue transmission—Lessons learned from a case-control study in northeastern Thailand
title_full_unstemmed Complex relationships between Aedes vectors, socio-economics and dengue transmission—Lessons learned from a case-control study in northeastern Thailand
title_short Complex relationships between Aedes vectors, socio-economics and dengue transmission—Lessons learned from a case-control study in northeastern Thailand
title_sort complex relationships between aedes vectors, socio-economics and dengue transmission—lessons learned from a case-control study in northeastern thailand
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7553337/
https://www.ncbi.nlm.nih.gov/pubmed/33001972
http://dx.doi.org/10.1371/journal.pntd.0008703
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