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Phenotype-genotype comorbidity analysis of patients with rare disorders provides insight into their pathological and molecular bases

Genetic and molecular analysis of rare disease is made difficult by the small numbers of affected patients. Phenotypic comorbidity analysis can help rectify this by combining information from individuals with similar phenotypes and looking for overlap in terms of shared genes and underlying function...

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Detalles Bibliográficos
Autores principales: Díaz-Santiago, Elena, Jabato, Fernando M., Rojano, Elena, Seoane, Pedro, Pazos, Florencio, Perkins, James R., Ranea, Juan A. G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7553355/
https://www.ncbi.nlm.nih.gov/pubmed/33001999
http://dx.doi.org/10.1371/journal.pgen.1009054

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