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Correlation of liver-to-spleen ratio, lung CT scores, clinical, and laboratory findings of COVID-19 patients with two consecutive CT scans

PURPOSE: Given the lack of information about abdominal imaging findings and correlation with clinical features of COVID-19, we aimed to evaluate the changes in hepatic attenuation during the course of disease. Our aim was to correlate the liver-to-spleen ratio (L/S), clinical, laboratory findings, a...

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Autores principales: Guler, Ezgi, Unal, Nalan Gulsen, Cinkooglu, Akin, Savas, Recep, Kose, Timur, Pullukcu, Husnu, Harman, Mustafa, Elmas, Nevra Z., Ramaiya, Nikhil H., Ozutemiz, Ahmet Omer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7553377/
https://www.ncbi.nlm.nih.gov/pubmed/33051758
http://dx.doi.org/10.1007/s00261-020-02805-y
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author Guler, Ezgi
Unal, Nalan Gulsen
Cinkooglu, Akin
Savas, Recep
Kose, Timur
Pullukcu, Husnu
Harman, Mustafa
Elmas, Nevra Z.
Ramaiya, Nikhil H.
Ozutemiz, Ahmet Omer
author_facet Guler, Ezgi
Unal, Nalan Gulsen
Cinkooglu, Akin
Savas, Recep
Kose, Timur
Pullukcu, Husnu
Harman, Mustafa
Elmas, Nevra Z.
Ramaiya, Nikhil H.
Ozutemiz, Ahmet Omer
author_sort Guler, Ezgi
collection PubMed
description PURPOSE: Given the lack of information about abdominal imaging findings and correlation with clinical features of COVID-19, we aimed to evaluate the changes in hepatic attenuation during the course of disease. Our aim was to correlate the liver-to-spleen ratio (L/S), clinical, laboratory findings, and lung CT scores of patients with COVID-19 who had two consecutive chest CTs. METHODS: A retrospective search was performed between March 1, 2020 and April 26, 2020 to identify patients who had positive RT-PCR tests and two unenhanced chest CTs. Scans that were obtained at hospital admission and follow-up were reviewed to assess L/S and lung CT scores. Patients were divided into two groups based on lung CT scores (non-progressive vs progressive). Patient demographics, laboratory findings, length of hospital stay, and survival were noted from electronic medical records. RESULTS: Twenty patients in the progressive group and 7 patients in the non-progressive group were identified. The mean L/S of the progressive group (1.13 ± 0.3) was lower than that of the non-progressive group (1.21 ± 0.29) at hospital admission but there was no significant difference between the two groups (p = 0.547). L/S at follow-up was significantly different between the groups as the mean L/S values of the progressive and non-progressive groups were 1.02 ± 0.23 and 1.25 ± 0.29, respectively (p = 0.009). L/S was negatively correlated with AST and ALT (r =  − 0.46, p = 0.016 and r =  − 0.534, p = 0.004, respectively). There were significant differences between the two groups in terms of WBC, neutrophil, lymphocyte, monocyte, and platelet counts that were obtained at hospital admission. Length of hospital stay was significantly longer in patients in the progressive group (p = 0.035). CONCLUSIONS: Decrease in L/S may be observed in patients with elevated lung CT scores at follow-up. WBC, neutrophil, lymphocyte, monocyte, and platelet counts at hospital admission may predict the progression of COVID-19.
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spelling pubmed-75533772020-10-14 Correlation of liver-to-spleen ratio, lung CT scores, clinical, and laboratory findings of COVID-19 patients with two consecutive CT scans Guler, Ezgi Unal, Nalan Gulsen Cinkooglu, Akin Savas, Recep Kose, Timur Pullukcu, Husnu Harman, Mustafa Elmas, Nevra Z. Ramaiya, Nikhil H. Ozutemiz, Ahmet Omer Abdom Radiol (NY) Hepatobiliary PURPOSE: Given the lack of information about abdominal imaging findings and correlation with clinical features of COVID-19, we aimed to evaluate the changes in hepatic attenuation during the course of disease. Our aim was to correlate the liver-to-spleen ratio (L/S), clinical, laboratory findings, and lung CT scores of patients with COVID-19 who had two consecutive chest CTs. METHODS: A retrospective search was performed between March 1, 2020 and April 26, 2020 to identify patients who had positive RT-PCR tests and two unenhanced chest CTs. Scans that were obtained at hospital admission and follow-up were reviewed to assess L/S and lung CT scores. Patients were divided into two groups based on lung CT scores (non-progressive vs progressive). Patient demographics, laboratory findings, length of hospital stay, and survival were noted from electronic medical records. RESULTS: Twenty patients in the progressive group and 7 patients in the non-progressive group were identified. The mean L/S of the progressive group (1.13 ± 0.3) was lower than that of the non-progressive group (1.21 ± 0.29) at hospital admission but there was no significant difference between the two groups (p = 0.547). L/S at follow-up was significantly different between the groups as the mean L/S values of the progressive and non-progressive groups were 1.02 ± 0.23 and 1.25 ± 0.29, respectively (p = 0.009). L/S was negatively correlated with AST and ALT (r =  − 0.46, p = 0.016 and r =  − 0.534, p = 0.004, respectively). There were significant differences between the two groups in terms of WBC, neutrophil, lymphocyte, monocyte, and platelet counts that were obtained at hospital admission. Length of hospital stay was significantly longer in patients in the progressive group (p = 0.035). CONCLUSIONS: Decrease in L/S may be observed in patients with elevated lung CT scores at follow-up. WBC, neutrophil, lymphocyte, monocyte, and platelet counts at hospital admission may predict the progression of COVID-19. Springer US 2020-10-13 2021 /pmc/articles/PMC7553377/ /pubmed/33051758 http://dx.doi.org/10.1007/s00261-020-02805-y Text en © Springer Science+Business Media, LLC, part of Springer Nature 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Hepatobiliary
Guler, Ezgi
Unal, Nalan Gulsen
Cinkooglu, Akin
Savas, Recep
Kose, Timur
Pullukcu, Husnu
Harman, Mustafa
Elmas, Nevra Z.
Ramaiya, Nikhil H.
Ozutemiz, Ahmet Omer
Correlation of liver-to-spleen ratio, lung CT scores, clinical, and laboratory findings of COVID-19 patients with two consecutive CT scans
title Correlation of liver-to-spleen ratio, lung CT scores, clinical, and laboratory findings of COVID-19 patients with two consecutive CT scans
title_full Correlation of liver-to-spleen ratio, lung CT scores, clinical, and laboratory findings of COVID-19 patients with two consecutive CT scans
title_fullStr Correlation of liver-to-spleen ratio, lung CT scores, clinical, and laboratory findings of COVID-19 patients with two consecutive CT scans
title_full_unstemmed Correlation of liver-to-spleen ratio, lung CT scores, clinical, and laboratory findings of COVID-19 patients with two consecutive CT scans
title_short Correlation of liver-to-spleen ratio, lung CT scores, clinical, and laboratory findings of COVID-19 patients with two consecutive CT scans
title_sort correlation of liver-to-spleen ratio, lung ct scores, clinical, and laboratory findings of covid-19 patients with two consecutive ct scans
topic Hepatobiliary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7553377/
https://www.ncbi.nlm.nih.gov/pubmed/33051758
http://dx.doi.org/10.1007/s00261-020-02805-y
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