Nonclinical Safety Assessment of AMG 553, an Investigational Chimeric Antigen Receptor T-Cell Therapy for the Treatment of Acute Myeloid Leukemia

Feline McDonough Sarcoma-like tyrosine kinase 3 (FLT3), a tyrosine-protein kinase involved in hematopoiesis, is detectable on the cell surface of approximately 80% of leukemia isolates from adult patients with acute myeloid leukemia (AML). AMG 553 is an investigational chimeric antigen receptor (CAR...

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Detalles Bibliográficos
Autores principales: Karbowski, Christine, Goldstein, Rebecca, Frank, Brendon, Kim, Kei, Li, Chi-Ming, Homann, Oliver, Hensley, Kelly, Brooks, Benjamin, Wang, Xiaoting, Yan, Qinghong, Hernandez, Rocio, Adams, Gregor, Boyle, Michael, Arvedson, Tara, Lebrec, Herve
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Clinical and Translational Toxicology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7553704/
https://www.ncbi.nlm.nih.gov/pubmed/32589753
http://dx.doi.org/10.1093/toxsci/kfaa098

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