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Characterization of the mechanism by which the RB/E2F pathway controls expression of the cancer genomic DNA deaminase APOBEC3B
APOBEC3B (A3B)-catalyzed DNA cytosine deamination contributes to the overall mutational landscape in breast cancer. Molecular mechanisms responsible for A3B upregulation in cancer are poorly understood. Here we show that a single E2F cis-element mediates repression in normal cells and that expressio...
Autores principales: | Roelofs, Pieter A, Goh, Chai Yeen, Chua, Boon Haow, Jarvis, Matthew C, Stewart, Teneale A, McCann, Jennifer L, McDougle, Rebecca M, Carpenter, Michael A, Martens, John WM, Span, Paul N, Kappei, Dennis, Harris, Reuben S |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7553775/ https://www.ncbi.nlm.nih.gov/pubmed/32985974 http://dx.doi.org/10.7554/eLife.61287 |
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