Molecular imaging of Alzheimer’s disease–related gamma-secretase in mice and nonhuman primates

The pathogenesis of Alzheimer’s disease (AD) is primarily driven by brain accumulation of the amyloid-β-42 (Aβ(42)) peptide generated from the amyloid-β precursor protein (APP) via cleavages by β- and γ-secretase. γ-Secretase is a prime drug target for AD; however, its brain regional expression and...

Descripción completa

Detalles Bibliográficos
Autores principales: Xu, Yulong, Wang, Changning, Wey, Hsiao-Ying, Liang, Yingxia, Chen, Zude, Choi, Se Hoon, Ran, Chongzhao, Rynearson, Kevin D., Bernales, Daniela R., Koegel, Robert E., Fiedler, Stephanie A., Striar, Robin, Wagner, Steven L., Tanzi, Rudolph E., Zhang, Can
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
Brief Definitive Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7553790/
https://www.ncbi.nlm.nih.gov/pubmed/32936886
http://dx.doi.org/10.1084/jem.20182266

Ejemplares similares

Ejemplares similares