Imaging of Hypoxic Tumor: Correlation between Diffusion-weighted MR Imaging and (18)F-fluoroazomycin Arabinoside Positron Emission Tomography in Head and Neck Carcinoma

We investigated the usefulness of diffusion-weighted imaging (DWI) for detecting changes in the structure of hypoxic cells by evaluating the correlation between (18)F-fluoroazomycin arabinoside (FAZA) positron emission tomography activity and DWI parameters in head and neck carcinoma. The diffusion...

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Detalles Bibliográficos
Autores principales: Imaizumi, Akiko, Obata, Takayuki, Kershaw, Jeff, Tachibana, Yasuhiko, Inubushi, Masayuki, Koizumi, Mitsuru, Yoshikawa, Kyosan, Zhang, Ming-Rong, Tanimoto, Katsuyuki, Harada, Rintaro, Uno, Takashi, Saga, Tsuneo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society for Magnetic Resonance in Medicine 2019
Materias:
Technical Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7553815/
https://www.ncbi.nlm.nih.gov/pubmed/31548478
http://dx.doi.org/10.2463/mrms.tn.2019-0007
Descripción
Sumario:We investigated the usefulness of diffusion-weighted imaging (DWI) for detecting changes in the structure of hypoxic cells by evaluating the correlation between (18)F-fluoroazomycin arabinoside (FAZA) positron emission tomography activity and DWI parameters in head and neck carcinoma. The diffusion coefficient corresponding to the slow compartment of a two-compartment model had a significant positive correlation with FAZA activity (ρ = 0.58, P = 0.016), whereas the diffusional kurtosis from diffusion kurtosis imaging had a significant negative correlation (ρ = −0.62, P = 0.008), which suggests that those DWI parameters might be useful as indicators for changes in cell structure.

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