Imaging of Hypoxic Tumor: Correlation between Diffusion-weighted MR Imaging and (18)F-fluoroazomycin Arabinoside Positron Emission Tomography in Head and Neck Carcinoma

We investigated the usefulness of diffusion-weighted imaging (DWI) for detecting changes in the structure of hypoxic cells by evaluating the correlation between (18)F-fluoroazomycin arabinoside (FAZA) positron emission tomography activity and DWI parameters in head and neck carcinoma. The diffusion...

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Autores principales: Imaizumi, Akiko, Obata, Takayuki, Kershaw, Jeff, Tachibana, Yasuhiko, Inubushi, Masayuki, Koizumi, Mitsuru, Yoshikawa, Kyosan, Zhang, Ming-Rong, Tanimoto, Katsuyuki, Harada, Rintaro, Uno, Takashi, Saga, Tsuneo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Society for Magnetic Resonance in Medicine 2019
Materias:
Technical Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7553815/
https://www.ncbi.nlm.nih.gov/pubmed/31548478
http://dx.doi.org/10.2463/mrms.tn.2019-0007
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author Imaizumi, Akiko
Obata, Takayuki
Kershaw, Jeff
Tachibana, Yasuhiko
Inubushi, Masayuki
Koizumi, Mitsuru
Yoshikawa, Kyosan
Zhang, Ming-Rong
Tanimoto, Katsuyuki
Harada, Rintaro
Uno, Takashi
Saga, Tsuneo
author_facet Imaizumi, Akiko
Obata, Takayuki
Kershaw, Jeff
Tachibana, Yasuhiko
Inubushi, Masayuki
Koizumi, Mitsuru
Yoshikawa, Kyosan
Zhang, Ming-Rong
Tanimoto, Katsuyuki
Harada, Rintaro
Uno, Takashi
Saga, Tsuneo
author_sort Imaizumi, Akiko
collection PubMed
description We investigated the usefulness of diffusion-weighted imaging (DWI) for detecting changes in the structure of hypoxic cells by evaluating the correlation between (18)F-fluoroazomycin arabinoside (FAZA) positron emission tomography activity and DWI parameters in head and neck carcinoma. The diffusion coefficient corresponding to the slow compartment of a two-compartment model had a significant positive correlation with FAZA activity (ρ = 0.58, P = 0.016), whereas the diffusional kurtosis from diffusion kurtosis imaging had a significant negative correlation (ρ = −0.62, P = 0.008), which suggests that those DWI parameters might be useful as indicators for changes in cell structure.
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spelling pubmed-75538152020-10-26 Imaging of Hypoxic Tumor: Correlation between Diffusion-weighted MR Imaging and (18)F-fluoroazomycin Arabinoside Positron Emission Tomography in Head and Neck Carcinoma Imaizumi, Akiko Obata, Takayuki Kershaw, Jeff Tachibana, Yasuhiko Inubushi, Masayuki Koizumi, Mitsuru Yoshikawa, Kyosan Zhang, Ming-Rong Tanimoto, Katsuyuki Harada, Rintaro Uno, Takashi Saga, Tsuneo Magn Reson Med Sci Technical Note We investigated the usefulness of diffusion-weighted imaging (DWI) for detecting changes in the structure of hypoxic cells by evaluating the correlation between (18)F-fluoroazomycin arabinoside (FAZA) positron emission tomography activity and DWI parameters in head and neck carcinoma. The diffusion coefficient corresponding to the slow compartment of a two-compartment model had a significant positive correlation with FAZA activity (ρ = 0.58, P = 0.016), whereas the diffusional kurtosis from diffusion kurtosis imaging had a significant negative correlation (ρ = −0.62, P = 0.008), which suggests that those DWI parameters might be useful as indicators for changes in cell structure. Japanese Society for Magnetic Resonance in Medicine 2019-09-24 /pmc/articles/PMC7553815/ /pubmed/31548478 http://dx.doi.org/10.2463/mrms.tn.2019-0007 Text en © 2019 Japanese Society for Magnetic Resonance in Medicine This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/
spellingShingle Technical Note
Imaizumi, Akiko
Obata, Takayuki
Kershaw, Jeff
Tachibana, Yasuhiko
Inubushi, Masayuki
Koizumi, Mitsuru
Yoshikawa, Kyosan
Zhang, Ming-Rong
Tanimoto, Katsuyuki
Harada, Rintaro
Uno, Takashi
Saga, Tsuneo
Imaging of Hypoxic Tumor: Correlation between Diffusion-weighted MR Imaging and (18)F-fluoroazomycin Arabinoside Positron Emission Tomography in Head and Neck Carcinoma
title Imaging of Hypoxic Tumor: Correlation between Diffusion-weighted MR Imaging and (18)F-fluoroazomycin Arabinoside Positron Emission Tomography in Head and Neck Carcinoma
title_full Imaging of Hypoxic Tumor: Correlation between Diffusion-weighted MR Imaging and (18)F-fluoroazomycin Arabinoside Positron Emission Tomography in Head and Neck Carcinoma
title_fullStr Imaging of Hypoxic Tumor: Correlation between Diffusion-weighted MR Imaging and (18)F-fluoroazomycin Arabinoside Positron Emission Tomography in Head and Neck Carcinoma
title_full_unstemmed Imaging of Hypoxic Tumor: Correlation between Diffusion-weighted MR Imaging and (18)F-fluoroazomycin Arabinoside Positron Emission Tomography in Head and Neck Carcinoma
title_short Imaging of Hypoxic Tumor: Correlation between Diffusion-weighted MR Imaging and (18)F-fluoroazomycin Arabinoside Positron Emission Tomography in Head and Neck Carcinoma
title_sort imaging of hypoxic tumor: correlation between diffusion-weighted mr imaging and (18)f-fluoroazomycin arabinoside positron emission tomography in head and neck carcinoma
topic Technical Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7553815/
https://www.ncbi.nlm.nih.gov/pubmed/31548478
http://dx.doi.org/10.2463/mrms.tn.2019-0007
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