Soticlestat, a novel cholesterol 24-hydroxylase inhibitor shows a therapeutic potential for neural hyperexcitation in mice

Cholesterol 24-hydroxylase (CH24H) is a brain-specific enzyme that converts cholesterol into 24S-hydroxycholesterol, the primary mechanism of cholesterol catabolism in the brain. The therapeutic potential of CH24H activation has been extensively investigated, whereas the effects of CH24H inhibition...

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Detalles Bibliográficos
Autores principales: Nishi, Toshiya, Kondo, Shinichi, Miyamoto, Maki, Watanabe, Sayuri, Hasegawa, Shigeo, Kondo, Shigeru, Yano, Jason, Watanabe, Etsurou, Ishi, Tsuyoshi, Yoshikawa, Masato, Ando, Haruhi Kamisaki, Farnaby, William, Fujimoto, Shinji, Sunahara, Eiji, Ohori, Momoko, During, Matthew J., Kuroita, Takanobu, Koike, Tatsuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7553946/
https://www.ncbi.nlm.nih.gov/pubmed/33051477
http://dx.doi.org/10.1038/s41598-020-74036-6

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