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Mode of delivery, order of birth, parental age gap and autism spectrum disorder among Malaysian children: A case-control study

Rising prevalence of autism spectrum disorders (ASD) in the last decades has led research to focus on the diagnosis and identification of factors associated with ASD. This paper sought for possible factors that put children at risk for ASD. In this study, we investigated the association between ASD...

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Autores principales: Andoy Galvan, Jo Ann, Ramalingam, Prabhagari Nair, Patil, Sapna Shridhar, bin Shobri, Muhammad Aminul Syahmi, Chinna, Karuthan, Sahrir, Muhammad Sabri, Chidambaram, Kumarappan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7553970/
https://www.ncbi.nlm.nih.gov/pubmed/33083595
http://dx.doi.org/10.1016/j.heliyon.2020.e05068
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author Andoy Galvan, Jo Ann
Ramalingam, Prabhagari Nair
Patil, Sapna Shridhar
bin Shobri, Muhammad Aminul Syahmi
Chinna, Karuthan
Sahrir, Muhammad Sabri
Chidambaram, Kumarappan
author_facet Andoy Galvan, Jo Ann
Ramalingam, Prabhagari Nair
Patil, Sapna Shridhar
bin Shobri, Muhammad Aminul Syahmi
Chinna, Karuthan
Sahrir, Muhammad Sabri
Chidambaram, Kumarappan
author_sort Andoy Galvan, Jo Ann
collection PubMed
description Rising prevalence of autism spectrum disorders (ASD) in the last decades has led research to focus on the diagnosis and identification of factors associated with ASD. This paper sought for possible factors that put children at risk for ASD. In this study, we investigated the association between ASD and parental ages, parental age gaps, birth order and birth delivery method in Malaysian population. In this school-based case control study, 465 children with ASD 464 controls participated. Questionnaires were distributed to the parents of the selected children through the respective principals. Among the tested variables, Caesarean section (OR = 1.63, 95% CI 1.20, 2.20), earlier order of birth in the family (OR = 0.68, 95% CI 0.59, 0.77) and increasing gap in parental ages (OR = 1.04, 95% CI 1.001, 1.07) were significantly associated with ASD. This study concludes that Caesarean section, earlier order of birth in the family and increasing gap in parental age are independent risk factors for developing autism among Malaysian children.
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spelling pubmed-75539702020-10-19 Mode of delivery, order of birth, parental age gap and autism spectrum disorder among Malaysian children: A case-control study Andoy Galvan, Jo Ann Ramalingam, Prabhagari Nair Patil, Sapna Shridhar bin Shobri, Muhammad Aminul Syahmi Chinna, Karuthan Sahrir, Muhammad Sabri Chidambaram, Kumarappan Heliyon Research Article Rising prevalence of autism spectrum disorders (ASD) in the last decades has led research to focus on the diagnosis and identification of factors associated with ASD. This paper sought for possible factors that put children at risk for ASD. In this study, we investigated the association between ASD and parental ages, parental age gaps, birth order and birth delivery method in Malaysian population. In this school-based case control study, 465 children with ASD 464 controls participated. Questionnaires were distributed to the parents of the selected children through the respective principals. Among the tested variables, Caesarean section (OR = 1.63, 95% CI 1.20, 2.20), earlier order of birth in the family (OR = 0.68, 95% CI 0.59, 0.77) and increasing gap in parental ages (OR = 1.04, 95% CI 1.001, 1.07) were significantly associated with ASD. This study concludes that Caesarean section, earlier order of birth in the family and increasing gap in parental age are independent risk factors for developing autism among Malaysian children. Elsevier 2020-10-06 /pmc/articles/PMC7553970/ /pubmed/33083595 http://dx.doi.org/10.1016/j.heliyon.2020.e05068 Text en © 2020 The Authors. Published by Elsevier Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Research Article
Andoy Galvan, Jo Ann
Ramalingam, Prabhagari Nair
Patil, Sapna Shridhar
bin Shobri, Muhammad Aminul Syahmi
Chinna, Karuthan
Sahrir, Muhammad Sabri
Chidambaram, Kumarappan
Mode of delivery, order of birth, parental age gap and autism spectrum disorder among Malaysian children: A case-control study
title Mode of delivery, order of birth, parental age gap and autism spectrum disorder among Malaysian children: A case-control study
title_full Mode of delivery, order of birth, parental age gap and autism spectrum disorder among Malaysian children: A case-control study
title_fullStr Mode of delivery, order of birth, parental age gap and autism spectrum disorder among Malaysian children: A case-control study
title_full_unstemmed Mode of delivery, order of birth, parental age gap and autism spectrum disorder among Malaysian children: A case-control study
title_short Mode of delivery, order of birth, parental age gap and autism spectrum disorder among Malaysian children: A case-control study
title_sort mode of delivery, order of birth, parental age gap and autism spectrum disorder among malaysian children: a case-control study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7553970/
https://www.ncbi.nlm.nih.gov/pubmed/33083595
http://dx.doi.org/10.1016/j.heliyon.2020.e05068
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