Structure and Mechanism of B-family DNA Polymerase ζ Specialized for Translesion DNA Synthesis

DNA polymerase ζ (Polζ) belongs to the same B-family as high-fidelity replicative polymerases, and yet is specialized for the extension reaction in translesion DNA synthesis (TLS). Despite its importance in TLS, the structure of Polζ is unknown. We present cryo-EM structures of S.cerevisiae Polζ hol...

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Detalles Bibliográficos
Autores principales: Malik, Radhika, Kopylov, Mykhailo, Gomez-Llorente, Yacob, Jain, Rinku, Johnson, Robert E., Prakash, Louise, Prakash, Satya, Ubarretxena-Belandia, Iban, Aggarwal, Aneel K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554088/
https://www.ncbi.nlm.nih.gov/pubmed/32807989
http://dx.doi.org/10.1038/s41594-020-0476-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554088/
https://www.ncbi.nlm.nih.gov/pubmed/32807989
http://dx.doi.org/10.1038/s41594-020-0476-7

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