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Prenatal smoking and the risk of early childhood caries: A prospective cohort study

INTRODUCTION: Dental caries is a chronic complex disease of multifactorial etiology that affects a quarter of U.S. children. This study evaluated the association between prenatal smoking and offspring caries experience and used a negative control exposure analysis to assess if the association is cau...

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Autores principales: Akinkugbe, Aderonke A., Brickhouse, Tegwyn H., Nascimento, Marcelle M., Slade, Gary D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554205/
https://www.ncbi.nlm.nih.gov/pubmed/33083206
http://dx.doi.org/10.1016/j.pmedr.2020.101201
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author Akinkugbe, Aderonke A.
Brickhouse, Tegwyn H.
Nascimento, Marcelle M.
Slade, Gary D.
author_facet Akinkugbe, Aderonke A.
Brickhouse, Tegwyn H.
Nascimento, Marcelle M.
Slade, Gary D.
author_sort Akinkugbe, Aderonke A.
collection PubMed
description INTRODUCTION: Dental caries is a chronic complex disease of multifactorial etiology that affects a quarter of U.S. children. This study evaluated the association between prenatal smoking and offspring caries experience and used a negative control exposure analysis to assess if the association is causal. METHODS: Data from 1429 mother-offspring participants of the 1991/92 Avon Longitudinal Study of Parents and Children conducted in Bristol, England were analyzed. Prenatal smoking (yes v. no) and quantity smoked (none, <half pack, ≥half pack) were self-reported while offspring caries experience was determined by clinical oral examinations at 3 time points. Discrete time hazards regression estimated hazard odds of first occurrence of offspring caries, and substituted partner smoking for prenatal smoking in a negative control exposure analysis. RESULTS: Overall, 22% smoked during pregnancy while 36% of partners smoked. The adjusted hazard odds of first occurrence of caries experience in the offsprings of prenatal smokers compared to the offsprings of non-smokers was 1.42 (95% CI: 1.08, 1.86). Relative to non-smoking, smoking <half pack/day and ≥half pack/day during pregnancy were associated with higher adjusted hazard odds of offspring caries experience: 1.10 (95% CI: 0.79, 1.54) and 1.38 (0.98, 1.95) respectively. Partner smoking was associated with 33% (95% CI: 1.07, 1.65) higher adjusted hazard odds of first offspring caries experience occurrence. CONCLUSIONS: Prenatal and partner smoking appear associated with greater offspring caries experience. The positive association with partner smoking suggests either a shared genetic predisposition or unmeasured common environmental factors with the mother as opposed to a direct biological effect of the intrauterine environment.
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spelling pubmed-75542052020-10-19 Prenatal smoking and the risk of early childhood caries: A prospective cohort study Akinkugbe, Aderonke A. Brickhouse, Tegwyn H. Nascimento, Marcelle M. Slade, Gary D. Prev Med Rep Regular Article INTRODUCTION: Dental caries is a chronic complex disease of multifactorial etiology that affects a quarter of U.S. children. This study evaluated the association between prenatal smoking and offspring caries experience and used a negative control exposure analysis to assess if the association is causal. METHODS: Data from 1429 mother-offspring participants of the 1991/92 Avon Longitudinal Study of Parents and Children conducted in Bristol, England were analyzed. Prenatal smoking (yes v. no) and quantity smoked (none, <half pack, ≥half pack) were self-reported while offspring caries experience was determined by clinical oral examinations at 3 time points. Discrete time hazards regression estimated hazard odds of first occurrence of offspring caries, and substituted partner smoking for prenatal smoking in a negative control exposure analysis. RESULTS: Overall, 22% smoked during pregnancy while 36% of partners smoked. The adjusted hazard odds of first occurrence of caries experience in the offsprings of prenatal smokers compared to the offsprings of non-smokers was 1.42 (95% CI: 1.08, 1.86). Relative to non-smoking, smoking <half pack/day and ≥half pack/day during pregnancy were associated with higher adjusted hazard odds of offspring caries experience: 1.10 (95% CI: 0.79, 1.54) and 1.38 (0.98, 1.95) respectively. Partner smoking was associated with 33% (95% CI: 1.07, 1.65) higher adjusted hazard odds of first offspring caries experience occurrence. CONCLUSIONS: Prenatal and partner smoking appear associated with greater offspring caries experience. The positive association with partner smoking suggests either a shared genetic predisposition or unmeasured common environmental factors with the mother as opposed to a direct biological effect of the intrauterine environment. 2020-09-22 /pmc/articles/PMC7554205/ /pubmed/33083206 http://dx.doi.org/10.1016/j.pmedr.2020.101201 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Regular Article
Akinkugbe, Aderonke A.
Brickhouse, Tegwyn H.
Nascimento, Marcelle M.
Slade, Gary D.
Prenatal smoking and the risk of early childhood caries: A prospective cohort study
title Prenatal smoking and the risk of early childhood caries: A prospective cohort study
title_full Prenatal smoking and the risk of early childhood caries: A prospective cohort study
title_fullStr Prenatal smoking and the risk of early childhood caries: A prospective cohort study
title_full_unstemmed Prenatal smoking and the risk of early childhood caries: A prospective cohort study
title_short Prenatal smoking and the risk of early childhood caries: A prospective cohort study
title_sort prenatal smoking and the risk of early childhood caries: a prospective cohort study
topic Regular Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554205/
https://www.ncbi.nlm.nih.gov/pubmed/33083206
http://dx.doi.org/10.1016/j.pmedr.2020.101201
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