A case of recurrent herpes simplex 2 encephalitis, VZV reactivations, and dominant partial interferon-gamma-receptor-1 deficiency supports relevance of IFNgamma for antiviral defense in humans

BACKGROUND: Unlike infections with mycobacteria, reports of unusual viral infections in interferon-gamma-receptor (IFNγR) deficient patients are scarce. Therefore, discussion about increased susceptibility to viral infections in these patients is ongoing. CASE PRESENTATION: We describe a 51-year-old...

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Autores principales: Körholz, Julia, Richter, Nicole, Schäfer, Jochen, Schuetz, Catharina, Roesler, Joachim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554277/
https://www.ncbi.nlm.nih.gov/pubmed/33051801
http://dx.doi.org/10.1186/s40348-020-00106-4
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author Körholz, Julia
Richter, Nicole
Schäfer, Jochen
Schuetz, Catharina
Roesler, Joachim
author_facet Körholz, Julia
Richter, Nicole
Schäfer, Jochen
Schuetz, Catharina
Roesler, Joachim
author_sort Körholz, Julia
collection PubMed
description BACKGROUND: Unlike infections with mycobacteria, reports of unusual viral infections in interferon-gamma-receptor (IFNγR) deficient patients are scarce. Therefore, discussion about increased susceptibility to viral infections in these patients is ongoing. CASE PRESENTATION: We describe a 51-year-old male with dominant partial interferon-gamma-receptor-1 (IFNγR1)-deficiency and recurrent Herpes simplex 2 meningoencephalitis as well as other viral reactivations since childhood. CONCLUSIONS: This case further confirms an enhanced risk for viral disease in IFNγR-deficient patients and a role of interferon gamma for human antiviral defense.
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spelling pubmed-75542772020-10-19 A case of recurrent herpes simplex 2 encephalitis, VZV reactivations, and dominant partial interferon-gamma-receptor-1 deficiency supports relevance of IFNgamma for antiviral defense in humans Körholz, Julia Richter, Nicole Schäfer, Jochen Schuetz, Catharina Roesler, Joachim Mol Cell Pediatr Case Report BACKGROUND: Unlike infections with mycobacteria, reports of unusual viral infections in interferon-gamma-receptor (IFNγR) deficient patients are scarce. Therefore, discussion about increased susceptibility to viral infections in these patients is ongoing. CASE PRESENTATION: We describe a 51-year-old male with dominant partial interferon-gamma-receptor-1 (IFNγR1)-deficiency and recurrent Herpes simplex 2 meningoencephalitis as well as other viral reactivations since childhood. CONCLUSIONS: This case further confirms an enhanced risk for viral disease in IFNγR-deficient patients and a role of interferon gamma for human antiviral defense. Springer Berlin Heidelberg 2020-10-14 /pmc/articles/PMC7554277/ /pubmed/33051801 http://dx.doi.org/10.1186/s40348-020-00106-4 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Case Report
Körholz, Julia
Richter, Nicole
Schäfer, Jochen
Schuetz, Catharina
Roesler, Joachim
A case of recurrent herpes simplex 2 encephalitis, VZV reactivations, and dominant partial interferon-gamma-receptor-1 deficiency supports relevance of IFNgamma for antiviral defense in humans
title A case of recurrent herpes simplex 2 encephalitis, VZV reactivations, and dominant partial interferon-gamma-receptor-1 deficiency supports relevance of IFNgamma for antiviral defense in humans
title_full A case of recurrent herpes simplex 2 encephalitis, VZV reactivations, and dominant partial interferon-gamma-receptor-1 deficiency supports relevance of IFNgamma for antiviral defense in humans
title_fullStr A case of recurrent herpes simplex 2 encephalitis, VZV reactivations, and dominant partial interferon-gamma-receptor-1 deficiency supports relevance of IFNgamma for antiviral defense in humans
title_full_unstemmed A case of recurrent herpes simplex 2 encephalitis, VZV reactivations, and dominant partial interferon-gamma-receptor-1 deficiency supports relevance of IFNgamma for antiviral defense in humans
title_short A case of recurrent herpes simplex 2 encephalitis, VZV reactivations, and dominant partial interferon-gamma-receptor-1 deficiency supports relevance of IFNgamma for antiviral defense in humans
title_sort case of recurrent herpes simplex 2 encephalitis, vzv reactivations, and dominant partial interferon-gamma-receptor-1 deficiency supports relevance of ifngamma for antiviral defense in humans
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554277/
https://www.ncbi.nlm.nih.gov/pubmed/33051801
http://dx.doi.org/10.1186/s40348-020-00106-4
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