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Exploring the Role of TRIP-Brs in Human Breast Cancer: An Investigation of Expression, Clinicopathological Significance, and Prognosis

TRIP-Brs, a group of transcription factors (TFs) that modulate several mechanisms in higher organisms. However, the novel paradigm to target TRIP-Brs in specific cancer remains to be deciphered. In particular, comprehensive analysis of TRIP-Brs in clinicopathological and patients’ prognosis, especia...

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Autores principales: Mongre, Raj Kumar, Mishra, Chandra Bhushan, Jung, Samil, Lee, Beom Suk, Quynh, Nguyen Thi Ngoc, Anh, Nguyen Hai, Myagmarjav, Davaajragal, Jo, Taeyeon, Lee, Myeong-Sok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554327/
https://www.ncbi.nlm.nih.gov/pubmed/33102693
http://dx.doi.org/10.1016/j.omto.2020.09.003
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author Mongre, Raj Kumar
Mishra, Chandra Bhushan
Jung, Samil
Lee, Beom Suk
Quynh, Nguyen Thi Ngoc
Anh, Nguyen Hai
Myagmarjav, Davaajragal
Jo, Taeyeon
Lee, Myeong-Sok
author_facet Mongre, Raj Kumar
Mishra, Chandra Bhushan
Jung, Samil
Lee, Beom Suk
Quynh, Nguyen Thi Ngoc
Anh, Nguyen Hai
Myagmarjav, Davaajragal
Jo, Taeyeon
Lee, Myeong-Sok
author_sort Mongre, Raj Kumar
collection PubMed
description TRIP-Brs, a group of transcription factors (TFs) that modulate several mechanisms in higher organisms. However, the novel paradigm to target TRIP-Brs in specific cancer remains to be deciphered. In particular, comprehensive analysis of TRIP-Brs in clinicopathological and patients’ prognosis, especially in breast cancer (BRCA), is being greatly ignored. Therefore, we explored the key roles of TRIP-Br expression, modulatory effects, mutations, immune infiltration, and prognosis in BRCA using multidimensional approaches. We found elevated levels of TRIP-Brs in numerous cancer tissues than normal. Higher expression of TRIP-Br-2/4/5 was shown to be positively associated with lower survival, tumor grade, and malignancy of patients with BRCA. Additionally, higher TRIP-Br-3/4 were also significantly linked with worse/short survival of BRCA patients. TRIP-Br-1/4/5 were significantly overexpressed and enhanced tumorigenesis in large-scale BRCA datasets. The mRNA levels of TRIP-Brs have been also correlated with tumor immune infiltrate in BRCA patients. In addition, TRIP-Brs synergistically play a pivotal role in central carbon metabolism, cancer-associated pathways, cell cycle, and thyroid hormone signaling, which evoke that TRIP-Brs may be a potential target for the therapy of BRCA. Thus, this investigation may lay a foundation for further research on TRIP-Br-mediated management of BRCA.
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spelling pubmed-75543272020-10-22 Exploring the Role of TRIP-Brs in Human Breast Cancer: An Investigation of Expression, Clinicopathological Significance, and Prognosis Mongre, Raj Kumar Mishra, Chandra Bhushan Jung, Samil Lee, Beom Suk Quynh, Nguyen Thi Ngoc Anh, Nguyen Hai Myagmarjav, Davaajragal Jo, Taeyeon Lee, Myeong-Sok Mol Ther Oncolytics Original Article TRIP-Brs, a group of transcription factors (TFs) that modulate several mechanisms in higher organisms. However, the novel paradigm to target TRIP-Brs in specific cancer remains to be deciphered. In particular, comprehensive analysis of TRIP-Brs in clinicopathological and patients’ prognosis, especially in breast cancer (BRCA), is being greatly ignored. Therefore, we explored the key roles of TRIP-Br expression, modulatory effects, mutations, immune infiltration, and prognosis in BRCA using multidimensional approaches. We found elevated levels of TRIP-Brs in numerous cancer tissues than normal. Higher expression of TRIP-Br-2/4/5 was shown to be positively associated with lower survival, tumor grade, and malignancy of patients with BRCA. Additionally, higher TRIP-Br-3/4 were also significantly linked with worse/short survival of BRCA patients. TRIP-Br-1/4/5 were significantly overexpressed and enhanced tumorigenesis in large-scale BRCA datasets. The mRNA levels of TRIP-Brs have been also correlated with tumor immune infiltrate in BRCA patients. In addition, TRIP-Brs synergistically play a pivotal role in central carbon metabolism, cancer-associated pathways, cell cycle, and thyroid hormone signaling, which evoke that TRIP-Brs may be a potential target for the therapy of BRCA. Thus, this investigation may lay a foundation for further research on TRIP-Br-mediated management of BRCA. American Society of Gene & Cell Therapy 2020-09-16 /pmc/articles/PMC7554327/ /pubmed/33102693 http://dx.doi.org/10.1016/j.omto.2020.09.003 Text en © 2020 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Original Article
Mongre, Raj Kumar
Mishra, Chandra Bhushan
Jung, Samil
Lee, Beom Suk
Quynh, Nguyen Thi Ngoc
Anh, Nguyen Hai
Myagmarjav, Davaajragal
Jo, Taeyeon
Lee, Myeong-Sok
Exploring the Role of TRIP-Brs in Human Breast Cancer: An Investigation of Expression, Clinicopathological Significance, and Prognosis
title Exploring the Role of TRIP-Brs in Human Breast Cancer: An Investigation of Expression, Clinicopathological Significance, and Prognosis
title_full Exploring the Role of TRIP-Brs in Human Breast Cancer: An Investigation of Expression, Clinicopathological Significance, and Prognosis
title_fullStr Exploring the Role of TRIP-Brs in Human Breast Cancer: An Investigation of Expression, Clinicopathological Significance, and Prognosis
title_full_unstemmed Exploring the Role of TRIP-Brs in Human Breast Cancer: An Investigation of Expression, Clinicopathological Significance, and Prognosis
title_short Exploring the Role of TRIP-Brs in Human Breast Cancer: An Investigation of Expression, Clinicopathological Significance, and Prognosis
title_sort exploring the role of trip-brs in human breast cancer: an investigation of expression, clinicopathological significance, and prognosis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554327/
https://www.ncbi.nlm.nih.gov/pubmed/33102693
http://dx.doi.org/10.1016/j.omto.2020.09.003
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