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Computational Verification of Large Logical Models—Application to the Prediction of T Cell Response to Checkpoint Inhibitors
At the crossroad between biology and mathematical modeling, computational systems biology can contribute to a mechanistic understanding of high-level biological phenomenon. But as knowledge accumulates, the size and complexity of mathematical models increase, calling for the development of efficient...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554341/ https://www.ncbi.nlm.nih.gov/pubmed/33101049 http://dx.doi.org/10.3389/fphys.2020.558606 |
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author | Hernandez, Céline Thomas-Chollier, Morgane Naldi, Aurélien Thieffry, Denis |
author_facet | Hernandez, Céline Thomas-Chollier, Morgane Naldi, Aurélien Thieffry, Denis |
author_sort | Hernandez, Céline |
collection | PubMed |
description | At the crossroad between biology and mathematical modeling, computational systems biology can contribute to a mechanistic understanding of high-level biological phenomenon. But as knowledge accumulates, the size and complexity of mathematical models increase, calling for the development of efficient dynamical analysis methods. Here, we propose the use of two approaches for the development and analysis of complex cellular network models. A first approach, called "model verification" and inspired by unitary testing in software development, enables the formalization and automated verification of validation criteria for whole models or selected sub-parts. When combined with efficient analysis methods, this approach is suitable for continuous testing, thereby greatly facilitating model development. A second approach, called "value propagation," enables efficient analytical computation of the impact of specific environmental or genetic conditions on the dynamical behavior of some models. We apply these two approaches to the delineation and the analysis of a comprehensive model for T cell activation, taking into account CTLA4 and PD-1 checkpoint inhibitory pathways. While model verification greatly eases the delineation of logical rules complying with a set of dynamical specifications, propagation provides interesting insights into the different potential of CTLA4 and PD-1 immunotherapies. Both methods are implemented and made available in the all-inclusive CoLoMoTo Docker image, while the different steps of the model analysis are fully reported in two companion interactive jupyter notebooks, thereby ensuring the reproduction of our results. |
format | Online Article Text |
id | pubmed-7554341 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-75543412020-10-22 Computational Verification of Large Logical Models—Application to the Prediction of T Cell Response to Checkpoint Inhibitors Hernandez, Céline Thomas-Chollier, Morgane Naldi, Aurélien Thieffry, Denis Front Physiol Physiology At the crossroad between biology and mathematical modeling, computational systems biology can contribute to a mechanistic understanding of high-level biological phenomenon. But as knowledge accumulates, the size and complexity of mathematical models increase, calling for the development of efficient dynamical analysis methods. Here, we propose the use of two approaches for the development and analysis of complex cellular network models. A first approach, called "model verification" and inspired by unitary testing in software development, enables the formalization and automated verification of validation criteria for whole models or selected sub-parts. When combined with efficient analysis methods, this approach is suitable for continuous testing, thereby greatly facilitating model development. A second approach, called "value propagation," enables efficient analytical computation of the impact of specific environmental or genetic conditions on the dynamical behavior of some models. We apply these two approaches to the delineation and the analysis of a comprehensive model for T cell activation, taking into account CTLA4 and PD-1 checkpoint inhibitory pathways. While model verification greatly eases the delineation of logical rules complying with a set of dynamical specifications, propagation provides interesting insights into the different potential of CTLA4 and PD-1 immunotherapies. Both methods are implemented and made available in the all-inclusive CoLoMoTo Docker image, while the different steps of the model analysis are fully reported in two companion interactive jupyter notebooks, thereby ensuring the reproduction of our results. Frontiers Media S.A. 2020-09-30 /pmc/articles/PMC7554341/ /pubmed/33101049 http://dx.doi.org/10.3389/fphys.2020.558606 Text en Copyright © 2020 Hernandez, Thomas-Chollier, Naldi and Thieffry. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Physiology Hernandez, Céline Thomas-Chollier, Morgane Naldi, Aurélien Thieffry, Denis Computational Verification of Large Logical Models—Application to the Prediction of T Cell Response to Checkpoint Inhibitors |
title | Computational Verification of Large Logical Models—Application to the Prediction of T Cell Response to Checkpoint Inhibitors |
title_full | Computational Verification of Large Logical Models—Application to the Prediction of T Cell Response to Checkpoint Inhibitors |
title_fullStr | Computational Verification of Large Logical Models—Application to the Prediction of T Cell Response to Checkpoint Inhibitors |
title_full_unstemmed | Computational Verification of Large Logical Models—Application to the Prediction of T Cell Response to Checkpoint Inhibitors |
title_short | Computational Verification of Large Logical Models—Application to the Prediction of T Cell Response to Checkpoint Inhibitors |
title_sort | computational verification of large logical models—application to the prediction of t cell response to checkpoint inhibitors |
topic | Physiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554341/ https://www.ncbi.nlm.nih.gov/pubmed/33101049 http://dx.doi.org/10.3389/fphys.2020.558606 |
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