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Perspectives on mechanistic implications of ROS inducers for targeting viral infections

In this perspective, we propose to leverage reactive oxygen species (ROS) induction as a potential therapeutic measure against viral infections. Our rationale for targeting RNA viral infections by pro-oxidants is routed on the mechanistic hypothesis that ROS based treatment paradigm could impair RNA...

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Autores principales: Nadhan, Revathy, Patra, Dipyaman, Krishnan, Neethu, Rajan, Arathi, Gopala, Srinivas, Ravi, Dashnamoorthy, Srinivas, Priya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554476/
https://www.ncbi.nlm.nih.gov/pubmed/33068588
http://dx.doi.org/10.1016/j.ejphar.2020.173621
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author Nadhan, Revathy
Patra, Dipyaman
Krishnan, Neethu
Rajan, Arathi
Gopala, Srinivas
Ravi, Dashnamoorthy
Srinivas, Priya
author_facet Nadhan, Revathy
Patra, Dipyaman
Krishnan, Neethu
Rajan, Arathi
Gopala, Srinivas
Ravi, Dashnamoorthy
Srinivas, Priya
author_sort Nadhan, Revathy
collection PubMed
description In this perspective, we propose to leverage reactive oxygen species (ROS) induction as a potential therapeutic measure against viral infections. Our rationale for targeting RNA viral infections by pro-oxidants is routed on the mechanistic hypothesis that ROS based treatment paradigm could impair RNA integrity faster than the other macromolecules. Though antiviral drugs with antioxidant properties confer potential abilities for preventing viral entry, those with pro-oxidant properties could induce the degradation of nascent viral RNA within the host cells, as RNAs are highly prone to ROS mediated degradation than DNA/proteins. We have previously established that Plumbagin is a highly potent ROS inducer, which acts through shifting of the host redox potential. Besides, it has been reported that Plumbagin treatment has the potential for interrupting viral RNA replication within the host cells. Since the on-going Corona Virus Disease - 2019 (COVID-19) global pandemic mediated by Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2) exhibits high infectivity, the development of appropriate antiviral therapeutic strategies remains to be an urgent unmet race against time. Therefore, additional experimental validation is warranted to determine the appropriateness of repurposable drug candidates, possibly ROS inducers, for fighting the pandemic which could lead to saving many lives from being lost to COVID-19.
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spelling pubmed-75544762020-10-14 Perspectives on mechanistic implications of ROS inducers for targeting viral infections Nadhan, Revathy Patra, Dipyaman Krishnan, Neethu Rajan, Arathi Gopala, Srinivas Ravi, Dashnamoorthy Srinivas, Priya Eur J Pharmacol Full Length Article In this perspective, we propose to leverage reactive oxygen species (ROS) induction as a potential therapeutic measure against viral infections. Our rationale for targeting RNA viral infections by pro-oxidants is routed on the mechanistic hypothesis that ROS based treatment paradigm could impair RNA integrity faster than the other macromolecules. Though antiviral drugs with antioxidant properties confer potential abilities for preventing viral entry, those with pro-oxidant properties could induce the degradation of nascent viral RNA within the host cells, as RNAs are highly prone to ROS mediated degradation than DNA/proteins. We have previously established that Plumbagin is a highly potent ROS inducer, which acts through shifting of the host redox potential. Besides, it has been reported that Plumbagin treatment has the potential for interrupting viral RNA replication within the host cells. Since the on-going Corona Virus Disease - 2019 (COVID-19) global pandemic mediated by Severe Acute Respiratory Syndrome Corona Virus-2 (SARS-CoV-2) exhibits high infectivity, the development of appropriate antiviral therapeutic strategies remains to be an urgent unmet race against time. Therefore, additional experimental validation is warranted to determine the appropriateness of repurposable drug candidates, possibly ROS inducers, for fighting the pandemic which could lead to saving many lives from being lost to COVID-19. Elsevier B.V. 2021-01-05 2020-10-14 /pmc/articles/PMC7554476/ /pubmed/33068588 http://dx.doi.org/10.1016/j.ejphar.2020.173621 Text en © 2020 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Full Length Article
Nadhan, Revathy
Patra, Dipyaman
Krishnan, Neethu
Rajan, Arathi
Gopala, Srinivas
Ravi, Dashnamoorthy
Srinivas, Priya
Perspectives on mechanistic implications of ROS inducers for targeting viral infections
title Perspectives on mechanistic implications of ROS inducers for targeting viral infections
title_full Perspectives on mechanistic implications of ROS inducers for targeting viral infections
title_fullStr Perspectives on mechanistic implications of ROS inducers for targeting viral infections
title_full_unstemmed Perspectives on mechanistic implications of ROS inducers for targeting viral infections
title_short Perspectives on mechanistic implications of ROS inducers for targeting viral infections
title_sort perspectives on mechanistic implications of ros inducers for targeting viral infections
topic Full Length Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554476/
https://www.ncbi.nlm.nih.gov/pubmed/33068588
http://dx.doi.org/10.1016/j.ejphar.2020.173621
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