Sensing Host Arginine Is Essential for Leishmania Parasites’ Intracellular Development

Arginine homeostasis in lysosomes is critical for the growth and metabolism of mammalian cells. Phagolysosomes of macrophages are the niche where the parasitic protozoan Leishmania resides and causes human leishmaniasis. During infection, parasites encounter arginine deprivation, which is monitored...

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Detalles Bibliográficos
Autores principales: Goldman-Pinkovich, Adele, Kannan, Sriram, Nitzan-Koren, Roni, Puri, Madhu, Pawar, Harsh, Bar-Avraham, Yael, McDonald, Jacquelyn, Sur, Aakash, Zhang, Wen-Wei, Matlashewski, Greg, Madhubala, Rentala, Michaeli, Shulamit, Myler, Peter J., Zilberstein, Dan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554669/
https://www.ncbi.nlm.nih.gov/pubmed/33051367
http://dx.doi.org/10.1128/mBio.02023-20

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