The Product of Matrix Metalloproteinase Cleavage of Doxorubicin Conjugate for Anticancer Drug Delivery: Calorimetric, Spectroscopic, and Molecular Dynamics Studies on Peptide–Doxorubicin Binding to DNA

Matrix metalloproteinases (MMPs) are extracellular matrix degradation factors, promoting cancer progression. Hence, they could provide an enzyme-assisted delivery of doxorubicin (DOX) in cancer treatment. In the current study, the intercalation process of DOX and tetrapeptide–DOX, the product of the...

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Detalles Bibliográficos
Autores principales: Butowska, Kamila, Żamojć, Krzysztof, Kogut, Mateusz, Kozak, Witold, Wyrzykowski, Dariusz, Wiczk, Wiesław, Czub, Jacek, Piosik, Jacek, Rak, Janusz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554696/
https://www.ncbi.nlm.nih.gov/pubmed/32967212
http://dx.doi.org/10.3390/ijms21186923

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554696/
https://www.ncbi.nlm.nih.gov/pubmed/32967212
http://dx.doi.org/10.3390/ijms21186923

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