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Red Blood Cells and Hemoglobin in Human Atherosclerosis and Related Arterial Diseases

As the main particulate component of the circulating blood, RBCs play major roles in physiological hemodynamics and impact all arterial wall pathologies. RBCs are the main determinant of blood viscosity, defining the frictional forces exerted by the blood on the arterial wall. This function is used...

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Detalles Bibliográficos
Autores principales: Michel, Jean-Baptiste, Martin-Ventura, José Luis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554753/
https://www.ncbi.nlm.nih.gov/pubmed/32942605
http://dx.doi.org/10.3390/ijms21186756
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author Michel, Jean-Baptiste
Martin-Ventura, José Luis
author_facet Michel, Jean-Baptiste
Martin-Ventura, José Luis
author_sort Michel, Jean-Baptiste
collection PubMed
description As the main particulate component of the circulating blood, RBCs play major roles in physiological hemodynamics and impact all arterial wall pathologies. RBCs are the main determinant of blood viscosity, defining the frictional forces exerted by the blood on the arterial wall. This function is used in phylogeny and ontogeny of the cardiovascular (CV) system, allowing the acquisition of vasomotricity adapted to local metabolic demands, and systemic arterial pressure after birth. In pathology, RBCs collide with the arterial wall, inducing both local retention of their membranous lipids and local hemolysis, releasing heme-Fe(++) with a high toxicity for arterial cells: endothelial and smooth muscle cells (SMCs) cardiomyocytes, neurons, etc. Specifically, overloading of cells by Fe(++) promotes cell death. This local hemolysis is an event associated with early and advanced stages of human atherosclerosis. Similarly, the permanent renewal of mural RBC clotting is the major support of oxidation in abdominal aortic aneurysm. In parallel, calcifications promote intramural hemorrhages, and hemorrhages promote an osteoblastic phenotypic shift of arterial wall cells. Different plasma or tissue systems are able, at least in part, to limit this injury by acting at the different levels of this system.
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spelling pubmed-75547532020-10-14 Red Blood Cells and Hemoglobin in Human Atherosclerosis and Related Arterial Diseases Michel, Jean-Baptiste Martin-Ventura, José Luis Int J Mol Sci Review As the main particulate component of the circulating blood, RBCs play major roles in physiological hemodynamics and impact all arterial wall pathologies. RBCs are the main determinant of blood viscosity, defining the frictional forces exerted by the blood on the arterial wall. This function is used in phylogeny and ontogeny of the cardiovascular (CV) system, allowing the acquisition of vasomotricity adapted to local metabolic demands, and systemic arterial pressure after birth. In pathology, RBCs collide with the arterial wall, inducing both local retention of their membranous lipids and local hemolysis, releasing heme-Fe(++) with a high toxicity for arterial cells: endothelial and smooth muscle cells (SMCs) cardiomyocytes, neurons, etc. Specifically, overloading of cells by Fe(++) promotes cell death. This local hemolysis is an event associated with early and advanced stages of human atherosclerosis. Similarly, the permanent renewal of mural RBC clotting is the major support of oxidation in abdominal aortic aneurysm. In parallel, calcifications promote intramural hemorrhages, and hemorrhages promote an osteoblastic phenotypic shift of arterial wall cells. Different plasma or tissue systems are able, at least in part, to limit this injury by acting at the different levels of this system. MDPI 2020-09-15 /pmc/articles/PMC7554753/ /pubmed/32942605 http://dx.doi.org/10.3390/ijms21186756 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Michel, Jean-Baptiste
Martin-Ventura, José Luis
Red Blood Cells and Hemoglobin in Human Atherosclerosis and Related Arterial Diseases
title Red Blood Cells and Hemoglobin in Human Atherosclerosis and Related Arterial Diseases
title_full Red Blood Cells and Hemoglobin in Human Atherosclerosis and Related Arterial Diseases
title_fullStr Red Blood Cells and Hemoglobin in Human Atherosclerosis and Related Arterial Diseases
title_full_unstemmed Red Blood Cells and Hemoglobin in Human Atherosclerosis and Related Arterial Diseases
title_short Red Blood Cells and Hemoglobin in Human Atherosclerosis and Related Arterial Diseases
title_sort red blood cells and hemoglobin in human atherosclerosis and related arterial diseases
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554753/
https://www.ncbi.nlm.nih.gov/pubmed/32942605
http://dx.doi.org/10.3390/ijms21186756
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