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Red Blood Cells and Hemoglobin in Human Atherosclerosis and Related Arterial Diseases
As the main particulate component of the circulating blood, RBCs play major roles in physiological hemodynamics and impact all arterial wall pathologies. RBCs are the main determinant of blood viscosity, defining the frictional forces exerted by the blood on the arterial wall. This function is used...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554753/ https://www.ncbi.nlm.nih.gov/pubmed/32942605 http://dx.doi.org/10.3390/ijms21186756 |
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author | Michel, Jean-Baptiste Martin-Ventura, José Luis |
author_facet | Michel, Jean-Baptiste Martin-Ventura, José Luis |
author_sort | Michel, Jean-Baptiste |
collection | PubMed |
description | As the main particulate component of the circulating blood, RBCs play major roles in physiological hemodynamics and impact all arterial wall pathologies. RBCs are the main determinant of blood viscosity, defining the frictional forces exerted by the blood on the arterial wall. This function is used in phylogeny and ontogeny of the cardiovascular (CV) system, allowing the acquisition of vasomotricity adapted to local metabolic demands, and systemic arterial pressure after birth. In pathology, RBCs collide with the arterial wall, inducing both local retention of their membranous lipids and local hemolysis, releasing heme-Fe(++) with a high toxicity for arterial cells: endothelial and smooth muscle cells (SMCs) cardiomyocytes, neurons, etc. Specifically, overloading of cells by Fe(++) promotes cell death. This local hemolysis is an event associated with early and advanced stages of human atherosclerosis. Similarly, the permanent renewal of mural RBC clotting is the major support of oxidation in abdominal aortic aneurysm. In parallel, calcifications promote intramural hemorrhages, and hemorrhages promote an osteoblastic phenotypic shift of arterial wall cells. Different plasma or tissue systems are able, at least in part, to limit this injury by acting at the different levels of this system. |
format | Online Article Text |
id | pubmed-7554753 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75547532020-10-14 Red Blood Cells and Hemoglobin in Human Atherosclerosis and Related Arterial Diseases Michel, Jean-Baptiste Martin-Ventura, José Luis Int J Mol Sci Review As the main particulate component of the circulating blood, RBCs play major roles in physiological hemodynamics and impact all arterial wall pathologies. RBCs are the main determinant of blood viscosity, defining the frictional forces exerted by the blood on the arterial wall. This function is used in phylogeny and ontogeny of the cardiovascular (CV) system, allowing the acquisition of vasomotricity adapted to local metabolic demands, and systemic arterial pressure after birth. In pathology, RBCs collide with the arterial wall, inducing both local retention of their membranous lipids and local hemolysis, releasing heme-Fe(++) with a high toxicity for arterial cells: endothelial and smooth muscle cells (SMCs) cardiomyocytes, neurons, etc. Specifically, overloading of cells by Fe(++) promotes cell death. This local hemolysis is an event associated with early and advanced stages of human atherosclerosis. Similarly, the permanent renewal of mural RBC clotting is the major support of oxidation in abdominal aortic aneurysm. In parallel, calcifications promote intramural hemorrhages, and hemorrhages promote an osteoblastic phenotypic shift of arterial wall cells. Different plasma or tissue systems are able, at least in part, to limit this injury by acting at the different levels of this system. MDPI 2020-09-15 /pmc/articles/PMC7554753/ /pubmed/32942605 http://dx.doi.org/10.3390/ijms21186756 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Michel, Jean-Baptiste Martin-Ventura, José Luis Red Blood Cells and Hemoglobin in Human Atherosclerosis and Related Arterial Diseases |
title | Red Blood Cells and Hemoglobin in Human Atherosclerosis and Related Arterial Diseases |
title_full | Red Blood Cells and Hemoglobin in Human Atherosclerosis and Related Arterial Diseases |
title_fullStr | Red Blood Cells and Hemoglobin in Human Atherosclerosis and Related Arterial Diseases |
title_full_unstemmed | Red Blood Cells and Hemoglobin in Human Atherosclerosis and Related Arterial Diseases |
title_short | Red Blood Cells and Hemoglobin in Human Atherosclerosis and Related Arterial Diseases |
title_sort | red blood cells and hemoglobin in human atherosclerosis and related arterial diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554753/ https://www.ncbi.nlm.nih.gov/pubmed/32942605 http://dx.doi.org/10.3390/ijms21186756 |
work_keys_str_mv | AT micheljeanbaptiste redbloodcellsandhemoglobininhumanatherosclerosisandrelatedarterialdiseases AT martinventurajoseluis redbloodcellsandhemoglobininhumanatherosclerosisandrelatedarterialdiseases |