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From Bench to Bedside in Tongue Muscle Cancer Invasion and Back again: Gross Anatomy, Microanatomy, Surgical Treatments and Basic Research

Tongue squamous cell carcinoma is the most common malignancy in the oral cavity. Despite advances in diagnosis and treatment, the prognosis of advanced states has not significantly improved. Depth of invasion, pattern of invasion such as tumor budding grade, lingual lymph node metastasis in early st...

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Autores principales: Calabrese, Luca, Bizzoca, Maria Eleonora, Grigolato, Roberto, Maffini, Fausto Antonio, Tagliabue, Marta, Negro, Rosa, Leuci, Stefania, Mignogna, Michele Davide, Lo Muzio, Lorenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554763/
https://www.ncbi.nlm.nih.gov/pubmed/32932638
http://dx.doi.org/10.3390/life10090197
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author Calabrese, Luca
Bizzoca, Maria Eleonora
Grigolato, Roberto
Maffini, Fausto Antonio
Tagliabue, Marta
Negro, Rosa
Leuci, Stefania
Mignogna, Michele Davide
Lo Muzio, Lorenzo
author_facet Calabrese, Luca
Bizzoca, Maria Eleonora
Grigolato, Roberto
Maffini, Fausto Antonio
Tagliabue, Marta
Negro, Rosa
Leuci, Stefania
Mignogna, Michele Davide
Lo Muzio, Lorenzo
author_sort Calabrese, Luca
collection PubMed
description Tongue squamous cell carcinoma is the most common malignancy in the oral cavity. Despite advances in diagnosis and treatment, the prognosis of advanced states has not significantly improved. Depth of invasion, pattern of invasion such as tumor budding grade, lingual lymph node metastasis in early stages, collective cell migration and circulating tumor cells in peripheral blood are some examples of the mechanisms that are currently receiving increasing attention in the evaluation of the prognosis of tongue cancers. Anatomic-based surgery showed that it is possible to improve loco-regional control of tongue cancer. In patients with a “T-N tract involvement”, there is significantly more distant recurrence (40%) in patients undergoing a compartmental tongue surgery. In general, the neoplastic infiltration of the lingual muscles is traced back to the finding of neoplastic tissue along the course of a muscle; however, the muscle fibers, due to their spatial conformation and the organization of the extracellular matrix, could influence the movement of tumor cells through the muscle, leaving its three-dimensional structure unchanged. We need to exclude the possibility that tongue muscle fibers represent a mechanism for the diffusion of cancer cells without muscle invasion.
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spelling pubmed-75547632020-10-14 From Bench to Bedside in Tongue Muscle Cancer Invasion and Back again: Gross Anatomy, Microanatomy, Surgical Treatments and Basic Research Calabrese, Luca Bizzoca, Maria Eleonora Grigolato, Roberto Maffini, Fausto Antonio Tagliabue, Marta Negro, Rosa Leuci, Stefania Mignogna, Michele Davide Lo Muzio, Lorenzo Life (Basel) Review Tongue squamous cell carcinoma is the most common malignancy in the oral cavity. Despite advances in diagnosis and treatment, the prognosis of advanced states has not significantly improved. Depth of invasion, pattern of invasion such as tumor budding grade, lingual lymph node metastasis in early stages, collective cell migration and circulating tumor cells in peripheral blood are some examples of the mechanisms that are currently receiving increasing attention in the evaluation of the prognosis of tongue cancers. Anatomic-based surgery showed that it is possible to improve loco-regional control of tongue cancer. In patients with a “T-N tract involvement”, there is significantly more distant recurrence (40%) in patients undergoing a compartmental tongue surgery. In general, the neoplastic infiltration of the lingual muscles is traced back to the finding of neoplastic tissue along the course of a muscle; however, the muscle fibers, due to their spatial conformation and the organization of the extracellular matrix, could influence the movement of tumor cells through the muscle, leaving its three-dimensional structure unchanged. We need to exclude the possibility that tongue muscle fibers represent a mechanism for the diffusion of cancer cells without muscle invasion. MDPI 2020-09-12 /pmc/articles/PMC7554763/ /pubmed/32932638 http://dx.doi.org/10.3390/life10090197 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Calabrese, Luca
Bizzoca, Maria Eleonora
Grigolato, Roberto
Maffini, Fausto Antonio
Tagliabue, Marta
Negro, Rosa
Leuci, Stefania
Mignogna, Michele Davide
Lo Muzio, Lorenzo
From Bench to Bedside in Tongue Muscle Cancer Invasion and Back again: Gross Anatomy, Microanatomy, Surgical Treatments and Basic Research
title From Bench to Bedside in Tongue Muscle Cancer Invasion and Back again: Gross Anatomy, Microanatomy, Surgical Treatments and Basic Research
title_full From Bench to Bedside in Tongue Muscle Cancer Invasion and Back again: Gross Anatomy, Microanatomy, Surgical Treatments and Basic Research
title_fullStr From Bench to Bedside in Tongue Muscle Cancer Invasion and Back again: Gross Anatomy, Microanatomy, Surgical Treatments and Basic Research
title_full_unstemmed From Bench to Bedside in Tongue Muscle Cancer Invasion and Back again: Gross Anatomy, Microanatomy, Surgical Treatments and Basic Research
title_short From Bench to Bedside in Tongue Muscle Cancer Invasion and Back again: Gross Anatomy, Microanatomy, Surgical Treatments and Basic Research
title_sort from bench to bedside in tongue muscle cancer invasion and back again: gross anatomy, microanatomy, surgical treatments and basic research
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554763/
https://www.ncbi.nlm.nih.gov/pubmed/32932638
http://dx.doi.org/10.3390/life10090197
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