Deletion of p53 and Hyper-Activation of PIK3CA in Keratin-15(+) Stem Cells Lead to the Development of Spontaneous Squamous Cell Carcinoma

Squamous cell carcinoma (SCC) is the second commonest type of skin cancer, and SCCs make up about 90% of head and neck cancers (HNSCCs). HNSCCs harbor two frequent molecular alterations, namely, gain-of-function alterations of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (P...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Samantha M. Y., Bian, Li, Nicklawsky, Andrew G., Krinsky, Alexandra L., Brunetti, Tonya, Woolaver, Rachel A., Wang, Xiaoguang, Chen, Zhangguo, Young, Christian D., Gao, Dexiang, Wang, Xiao-Jing, Wang, Jing H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554792/
https://www.ncbi.nlm.nih.gov/pubmed/32916850
http://dx.doi.org/10.3390/ijms21186585

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554792/
https://www.ncbi.nlm.nih.gov/pubmed/32916850
http://dx.doi.org/10.3390/ijms21186585

Ejemplares similares