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Deletion of p53 and Hyper-Activation of PIK3CA in Keratin-15(+) Stem Cells Lead to the Development of Spontaneous Squamous Cell Carcinoma

Squamous cell carcinoma (SCC) is the second commonest type of skin cancer, and SCCs make up about 90% of head and neck cancers (HNSCCs). HNSCCs harbor two frequent molecular alterations, namely, gain-of-function alterations of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (P...

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Detalles Bibliográficos
Autores principales:	Chen, Samantha M. Y., Bian, Li, Nicklawsky, Andrew G., Krinsky, Alexandra L., Brunetti, Tonya, Woolaver, Rachel A., Wang, Xiaoguang, Chen, Zhangguo, Young, Christian D., Gao, Dexiang, Wang, Xiao-Jing, Wang, Jing H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554792/ https://www.ncbi.nlm.nih.gov/pubmed/32916850 http://dx.doi.org/10.3390/ijms21186585

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