Cargando…

Stem Cells Secretome from Oral Tissue Could Represent a Promising Therapeutic Approach in COVID-19-Disease?

At present, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection has quickly become a health emergency because no specifics vaccines or drugs, at this moment, are available. Recent studies have shown that the transplantation of mesenchymal stem cells (MSCs) into Coronavirus Disease...

Descripción completa

Detalles Bibliográficos
Autores principales: Diomede, Francesca, Marconi, Guya D., Fonticoli, Luigia, Pizzicannella, Jacopo, Trubiani, Oriana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554818/
https://www.ncbi.nlm.nih.gov/pubmed/32957696
http://dx.doi.org/10.3390/ijms21186833
_version_ 1783593862452740096
author Diomede, Francesca
Marconi, Guya D.
Fonticoli, Luigia
Pizzicannella, Jacopo
Trubiani, Oriana
author_facet Diomede, Francesca
Marconi, Guya D.
Fonticoli, Luigia
Pizzicannella, Jacopo
Trubiani, Oriana
author_sort Diomede, Francesca
collection PubMed
description At present, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection has quickly become a health emergency because no specifics vaccines or drugs, at this moment, are available. Recent studies have shown that the transplantation of mesenchymal stem cells (MSCs) into Coronavirus Disease 2019 (COVID-19) patients could represent a promising strategy for the development of new therapeutic methods. We speculate and suggest that the secretome of human Oral Tissue Stem Cells (hOTSCs), for their immunomodulatory and anti-inflammatory specific properties, could exert beneficial effects on the COVID-19 patients through an innovative aerosolisation technique. This non-invasive technique can offer multiple advantages in prophylaxis, as well as the prevention and treatment of severe epidemic respiratory syndrome with minimum risk and optimal therapeutic effects. This has the potential to create a novel pathway towards immunomodulatory therapy for the treatment of COVID-19 positive patients.
format Online
Article
Text
id pubmed-7554818
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-75548182020-10-14 Stem Cells Secretome from Oral Tissue Could Represent a Promising Therapeutic Approach in COVID-19-Disease? Diomede, Francesca Marconi, Guya D. Fonticoli, Luigia Pizzicannella, Jacopo Trubiani, Oriana Int J Mol Sci Editorial At present, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection has quickly become a health emergency because no specifics vaccines or drugs, at this moment, are available. Recent studies have shown that the transplantation of mesenchymal stem cells (MSCs) into Coronavirus Disease 2019 (COVID-19) patients could represent a promising strategy for the development of new therapeutic methods. We speculate and suggest that the secretome of human Oral Tissue Stem Cells (hOTSCs), for their immunomodulatory and anti-inflammatory specific properties, could exert beneficial effects on the COVID-19 patients through an innovative aerosolisation technique. This non-invasive technique can offer multiple advantages in prophylaxis, as well as the prevention and treatment of severe epidemic respiratory syndrome with minimum risk and optimal therapeutic effects. This has the potential to create a novel pathway towards immunomodulatory therapy for the treatment of COVID-19 positive patients. MDPI 2020-09-17 /pmc/articles/PMC7554818/ /pubmed/32957696 http://dx.doi.org/10.3390/ijms21186833 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Editorial
Diomede, Francesca
Marconi, Guya D.
Fonticoli, Luigia
Pizzicannella, Jacopo
Trubiani, Oriana
Stem Cells Secretome from Oral Tissue Could Represent a Promising Therapeutic Approach in COVID-19-Disease?
title Stem Cells Secretome from Oral Tissue Could Represent a Promising Therapeutic Approach in COVID-19-Disease?
title_full Stem Cells Secretome from Oral Tissue Could Represent a Promising Therapeutic Approach in COVID-19-Disease?
title_fullStr Stem Cells Secretome from Oral Tissue Could Represent a Promising Therapeutic Approach in COVID-19-Disease?
title_full_unstemmed Stem Cells Secretome from Oral Tissue Could Represent a Promising Therapeutic Approach in COVID-19-Disease?
title_short Stem Cells Secretome from Oral Tissue Could Represent a Promising Therapeutic Approach in COVID-19-Disease?
title_sort stem cells secretome from oral tissue could represent a promising therapeutic approach in covid-19-disease?
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554818/
https://www.ncbi.nlm.nih.gov/pubmed/32957696
http://dx.doi.org/10.3390/ijms21186833
work_keys_str_mv AT diomedefrancesca stemcellssecretomefromoraltissuecouldrepresentapromisingtherapeuticapproachincovid19disease
AT marconiguyad stemcellssecretomefromoraltissuecouldrepresentapromisingtherapeuticapproachincovid19disease
AT fonticoliluigia stemcellssecretomefromoraltissuecouldrepresentapromisingtherapeuticapproachincovid19disease
AT pizzicannellajacopo stemcellssecretomefromoraltissuecouldrepresentapromisingtherapeuticapproachincovid19disease
AT trubianioriana stemcellssecretomefromoraltissuecouldrepresentapromisingtherapeuticapproachincovid19disease