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Prognostic Role and Clinical Significance of Tumor-Infiltrating Lymphocyte (TIL) and Programmed Death Ligand 1 (PD-L1) Expression in Triple-Negative Breast Cancer (TNBC): A Systematic Review and Meta-Analysis Study
This meta-analysis aimed to evaluate the prognostic value of tumor-infiltrating lymphocytes (TILs) and programmed death-ligand 1 (PD-L1), their associations with the clinicopathological characteristics, and the association between their levels in patients with triple-negative breast cancer (TNBC). P...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554852/ https://www.ncbi.nlm.nih.gov/pubmed/32957579 http://dx.doi.org/10.3390/diagnostics10090704 |
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author | Lotfinejad, Parisa Asghari Jafarabadi, Mohammad Abdoli Shadbad, Mahdi Kazemi, Tohid Pashazadeh, Fariba Sandoghchian Shotorbani, Siamak Jadidi Niaragh, Farhad Baghbanzadeh, Amir Vahed, Nafiseh Silvestris, Nicola Baradaran, Behzad |
author_facet | Lotfinejad, Parisa Asghari Jafarabadi, Mohammad Abdoli Shadbad, Mahdi Kazemi, Tohid Pashazadeh, Fariba Sandoghchian Shotorbani, Siamak Jadidi Niaragh, Farhad Baghbanzadeh, Amir Vahed, Nafiseh Silvestris, Nicola Baradaran, Behzad |
author_sort | Lotfinejad, Parisa |
collection | PubMed |
description | This meta-analysis aimed to evaluate the prognostic value of tumor-infiltrating lymphocytes (TILs) and programmed death-ligand 1 (PD-L1), their associations with the clinicopathological characteristics, and the association between their levels in patients with triple-negative breast cancer (TNBC). PubMed, EMBASE, Scopus, ProQuest, Web of Science, and Cochrane Library databases were searched to obtain the relevant papers. Seven studies with 1152 patients were included in this study. Like the level of TILs, there were no significant associations between PD-L1 expression and tumor size, tumor stage, lymph node metastasis, histological grade, and Ki67 (All p-values ≥ 0.05). Furthermore, there was no significant association between PD-L1 expression with overall survival (OS) and disease-free survival (DFS). In assessment of TILs and survival relationship, the results showed that a high level of TILs was associated with long-term OS (hazard ratios (HR) = 0.48, 95% CI: 0.30 to 0.77, p-value < 0.001) and DFS (HR = 0.53, 95% CI: 0.35 to 0.78, p-value < 0.001). The results displayed that tumoral PD-L1 expression was strongly associated with high levels of TILs in TNBC patients (OR = 8.34, 95% CI: 2.68 to 25.95, p-value < 0.001). In conclusion, the study has shown the prognostic value of TILs and a strong association between tumoral PD-L1 overexpression with TILs in TNBC patients. |
format | Online Article Text |
id | pubmed-7554852 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75548522020-10-14 Prognostic Role and Clinical Significance of Tumor-Infiltrating Lymphocyte (TIL) and Programmed Death Ligand 1 (PD-L1) Expression in Triple-Negative Breast Cancer (TNBC): A Systematic Review and Meta-Analysis Study Lotfinejad, Parisa Asghari Jafarabadi, Mohammad Abdoli Shadbad, Mahdi Kazemi, Tohid Pashazadeh, Fariba Sandoghchian Shotorbani, Siamak Jadidi Niaragh, Farhad Baghbanzadeh, Amir Vahed, Nafiseh Silvestris, Nicola Baradaran, Behzad Diagnostics (Basel) Review This meta-analysis aimed to evaluate the prognostic value of tumor-infiltrating lymphocytes (TILs) and programmed death-ligand 1 (PD-L1), their associations with the clinicopathological characteristics, and the association between their levels in patients with triple-negative breast cancer (TNBC). PubMed, EMBASE, Scopus, ProQuest, Web of Science, and Cochrane Library databases were searched to obtain the relevant papers. Seven studies with 1152 patients were included in this study. Like the level of TILs, there were no significant associations between PD-L1 expression and tumor size, tumor stage, lymph node metastasis, histological grade, and Ki67 (All p-values ≥ 0.05). Furthermore, there was no significant association between PD-L1 expression with overall survival (OS) and disease-free survival (DFS). In assessment of TILs and survival relationship, the results showed that a high level of TILs was associated with long-term OS (hazard ratios (HR) = 0.48, 95% CI: 0.30 to 0.77, p-value < 0.001) and DFS (HR = 0.53, 95% CI: 0.35 to 0.78, p-value < 0.001). The results displayed that tumoral PD-L1 expression was strongly associated with high levels of TILs in TNBC patients (OR = 8.34, 95% CI: 2.68 to 25.95, p-value < 0.001). In conclusion, the study has shown the prognostic value of TILs and a strong association between tumoral PD-L1 overexpression with TILs in TNBC patients. MDPI 2020-09-17 /pmc/articles/PMC7554852/ /pubmed/32957579 http://dx.doi.org/10.3390/diagnostics10090704 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Lotfinejad, Parisa Asghari Jafarabadi, Mohammad Abdoli Shadbad, Mahdi Kazemi, Tohid Pashazadeh, Fariba Sandoghchian Shotorbani, Siamak Jadidi Niaragh, Farhad Baghbanzadeh, Amir Vahed, Nafiseh Silvestris, Nicola Baradaran, Behzad Prognostic Role and Clinical Significance of Tumor-Infiltrating Lymphocyte (TIL) and Programmed Death Ligand 1 (PD-L1) Expression in Triple-Negative Breast Cancer (TNBC): A Systematic Review and Meta-Analysis Study |
title | Prognostic Role and Clinical Significance of Tumor-Infiltrating Lymphocyte (TIL) and Programmed Death Ligand 1 (PD-L1) Expression in Triple-Negative Breast Cancer (TNBC): A Systematic Review and Meta-Analysis Study |
title_full | Prognostic Role and Clinical Significance of Tumor-Infiltrating Lymphocyte (TIL) and Programmed Death Ligand 1 (PD-L1) Expression in Triple-Negative Breast Cancer (TNBC): A Systematic Review and Meta-Analysis Study |
title_fullStr | Prognostic Role and Clinical Significance of Tumor-Infiltrating Lymphocyte (TIL) and Programmed Death Ligand 1 (PD-L1) Expression in Triple-Negative Breast Cancer (TNBC): A Systematic Review and Meta-Analysis Study |
title_full_unstemmed | Prognostic Role and Clinical Significance of Tumor-Infiltrating Lymphocyte (TIL) and Programmed Death Ligand 1 (PD-L1) Expression in Triple-Negative Breast Cancer (TNBC): A Systematic Review and Meta-Analysis Study |
title_short | Prognostic Role and Clinical Significance of Tumor-Infiltrating Lymphocyte (TIL) and Programmed Death Ligand 1 (PD-L1) Expression in Triple-Negative Breast Cancer (TNBC): A Systematic Review and Meta-Analysis Study |
title_sort | prognostic role and clinical significance of tumor-infiltrating lymphocyte (til) and programmed death ligand 1 (pd-l1) expression in triple-negative breast cancer (tnbc): a systematic review and meta-analysis study |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554852/ https://www.ncbi.nlm.nih.gov/pubmed/32957579 http://dx.doi.org/10.3390/diagnostics10090704 |
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