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Body Fat Parameters, Glucose and Lipid Profiles, and Thyroid Hormone Levels in Schizophrenia Patients with or without Metabolic Syndrome

In this study, we aim to investigate associations between body fat parameters, glucose and lipid profiles, thyroid-stimulating hormone (TSH), and thyroid hormones (THs) levels in Tomsk-region schizophrenia patients depending upon the presence or absence of metabolic syndrome (MetS). A total of 156 p...

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Autores principales: Kornetova, Elena G., Kornetov, Alexander N., Mednova, Irina A., Lobacheva, Olga A., Gerasimova, Valeria I., Dubrovskaya, Viktoria V., Tolmachev, Ivan V., Semke, Arkadiy V., Loonen, Anton J. M., Bokhan, Nikolay A., Ivanova, Svetlana A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554913/
https://www.ncbi.nlm.nih.gov/pubmed/32927785
http://dx.doi.org/10.3390/diagnostics10090683
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author Kornetova, Elena G.
Kornetov, Alexander N.
Mednova, Irina A.
Lobacheva, Olga A.
Gerasimova, Valeria I.
Dubrovskaya, Viktoria V.
Tolmachev, Ivan V.
Semke, Arkadiy V.
Loonen, Anton J. M.
Bokhan, Nikolay A.
Ivanova, Svetlana A.
author_facet Kornetova, Elena G.
Kornetov, Alexander N.
Mednova, Irina A.
Lobacheva, Olga A.
Gerasimova, Valeria I.
Dubrovskaya, Viktoria V.
Tolmachev, Ivan V.
Semke, Arkadiy V.
Loonen, Anton J. M.
Bokhan, Nikolay A.
Ivanova, Svetlana A.
author_sort Kornetova, Elena G.
collection PubMed
description In this study, we aim to investigate associations between body fat parameters, glucose and lipid profiles, thyroid-stimulating hormone (TSH), and thyroid hormones (THs) levels in Tomsk-region schizophrenia patients depending upon the presence or absence of metabolic syndrome (MetS). A total of 156 psychiatric inpatients with schizophrenia who had been treated with antipsychotics for at least six months before entry were studied: 56 with and 100 without MetS. Reference groups consisted of general hospital inpatients with MetS and without schizophrenia (n = 35) and healthy individuals (n = 35). Statistical analyses were performed using the Mann–Whitney U-test, chi-square test, Spearman’s rank correlation coefficient, multiple regression analyses, and descriptive statistics. Patients with schizophrenia and MetS had significantly higher levels of free triiodothyronine (FT3) and thyroxine (FT4) compared to schizophrenia patients without MetS (3.68 [3.25; 5.50] vs. 3.24 [2.81; 3.66], p = 0.0001, and 12.68 [10.73; 15.54] vs. 10.81 [9.76; 12.3], p = 0.0001, in pmol/L, respectively). FT3 maintained an association with MetS (p = 0.0001), sex (p = 0.0001), age (p = 0.022), and high-density lipoproteins (p = 0.033). FT4 maintained an association with MetS (p = 0.0001), sex (p = 0.001), age (p = 0.014), and glucose (p = 0.009). The data obtained showed body fat parameters, glucose and lipid profiles, and THs levels in Western-Siberian schizophrenia patients depending on MetS presence or absence.
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spelling pubmed-75549132020-10-14 Body Fat Parameters, Glucose and Lipid Profiles, and Thyroid Hormone Levels in Schizophrenia Patients with or without Metabolic Syndrome Kornetova, Elena G. Kornetov, Alexander N. Mednova, Irina A. Lobacheva, Olga A. Gerasimova, Valeria I. Dubrovskaya, Viktoria V. Tolmachev, Ivan V. Semke, Arkadiy V. Loonen, Anton J. M. Bokhan, Nikolay A. Ivanova, Svetlana A. Diagnostics (Basel) Article In this study, we aim to investigate associations between body fat parameters, glucose and lipid profiles, thyroid-stimulating hormone (TSH), and thyroid hormones (THs) levels in Tomsk-region schizophrenia patients depending upon the presence or absence of metabolic syndrome (MetS). A total of 156 psychiatric inpatients with schizophrenia who had been treated with antipsychotics for at least six months before entry were studied: 56 with and 100 without MetS. Reference groups consisted of general hospital inpatients with MetS and without schizophrenia (n = 35) and healthy individuals (n = 35). Statistical analyses were performed using the Mann–Whitney U-test, chi-square test, Spearman’s rank correlation coefficient, multiple regression analyses, and descriptive statistics. Patients with schizophrenia and MetS had significantly higher levels of free triiodothyronine (FT3) and thyroxine (FT4) compared to schizophrenia patients without MetS (3.68 [3.25; 5.50] vs. 3.24 [2.81; 3.66], p = 0.0001, and 12.68 [10.73; 15.54] vs. 10.81 [9.76; 12.3], p = 0.0001, in pmol/L, respectively). FT3 maintained an association with MetS (p = 0.0001), sex (p = 0.0001), age (p = 0.022), and high-density lipoproteins (p = 0.033). FT4 maintained an association with MetS (p = 0.0001), sex (p = 0.001), age (p = 0.014), and glucose (p = 0.009). The data obtained showed body fat parameters, glucose and lipid profiles, and THs levels in Western-Siberian schizophrenia patients depending on MetS presence or absence. MDPI 2020-09-10 /pmc/articles/PMC7554913/ /pubmed/32927785 http://dx.doi.org/10.3390/diagnostics10090683 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kornetova, Elena G.
Kornetov, Alexander N.
Mednova, Irina A.
Lobacheva, Olga A.
Gerasimova, Valeria I.
Dubrovskaya, Viktoria V.
Tolmachev, Ivan V.
Semke, Arkadiy V.
Loonen, Anton J. M.
Bokhan, Nikolay A.
Ivanova, Svetlana A.
Body Fat Parameters, Glucose and Lipid Profiles, and Thyroid Hormone Levels in Schizophrenia Patients with or without Metabolic Syndrome
title Body Fat Parameters, Glucose and Lipid Profiles, and Thyroid Hormone Levels in Schizophrenia Patients with or without Metabolic Syndrome
title_full Body Fat Parameters, Glucose and Lipid Profiles, and Thyroid Hormone Levels in Schizophrenia Patients with or without Metabolic Syndrome
title_fullStr Body Fat Parameters, Glucose and Lipid Profiles, and Thyroid Hormone Levels in Schizophrenia Patients with or without Metabolic Syndrome
title_full_unstemmed Body Fat Parameters, Glucose and Lipid Profiles, and Thyroid Hormone Levels in Schizophrenia Patients with or without Metabolic Syndrome
title_short Body Fat Parameters, Glucose and Lipid Profiles, and Thyroid Hormone Levels in Schizophrenia Patients with or without Metabolic Syndrome
title_sort body fat parameters, glucose and lipid profiles, and thyroid hormone levels in schizophrenia patients with or without metabolic syndrome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554913/
https://www.ncbi.nlm.nih.gov/pubmed/32927785
http://dx.doi.org/10.3390/diagnostics10090683
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