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Combination of ACY-241 and JQ1 Synergistically Suppresses Metastasis of HNSCC via Regulation of MMP-2 and MMP-9

Overexpression of histone deacetylase 6 (HDAC6) and bromodomain-containing protein 4 (BRD4) is related to aggressiveness of head and neck squamous carcinoma (HNSCC). Based on studies that HDAC6 and BRD4 are potential therapeutic targets of HNSCC, we hypothesized that the combination treatment of BET...

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Detalles Bibliográficos
Autores principales:	Cho, Ha Young, Lee, Sang Wu, Jeon, Yu Hyun, Lee, Dong Hoon, Kim, Go Woon, Yoo, Jung, Kim, So Yeon, Kwon, So Hee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554925/ https://www.ncbi.nlm.nih.gov/pubmed/32961679 http://dx.doi.org/10.3390/ijms21186873

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