Cargando…

An Update on Vitamin D Metabolism

Vitamin D is a steroid hormone classically involved in the calcium metabolism and bone homeostasis. Recently, new and interesting aspects of vitamin D metabolism has been elucidated, namely the special role of the skin, the metabolic control of liver hydroxylase CYP2R1, the specificity of 1α-hydroxy...

Descripción completa

Detalles Bibliográficos
Autores principales: Saponaro, Federica, Saba, Alessandro, Zucchi, Riccardo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554947/
https://www.ncbi.nlm.nih.gov/pubmed/32911795
http://dx.doi.org/10.3390/ijms21186573
_version_ 1783593892742955008
author Saponaro, Federica
Saba, Alessandro
Zucchi, Riccardo
author_facet Saponaro, Federica
Saba, Alessandro
Zucchi, Riccardo
author_sort Saponaro, Federica
collection PubMed
description Vitamin D is a steroid hormone classically involved in the calcium metabolism and bone homeostasis. Recently, new and interesting aspects of vitamin D metabolism has been elucidated, namely the special role of the skin, the metabolic control of liver hydroxylase CYP2R1, the specificity of 1α-hydroxylase in different tissues and cell types and the genomic, non-genomic and epigenomic effects of vitamin D receptor, which will be addressed in the present review. Moreover, in the last decades, several extraskeletal effects which can be attributed to vitamin D have been shown. These beneficial effects will be here summarized, focusing on the immune system and cardiovascular system.
format Online
Article
Text
id pubmed-7554947
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-75549472020-10-14 An Update on Vitamin D Metabolism Saponaro, Federica Saba, Alessandro Zucchi, Riccardo Int J Mol Sci Review Vitamin D is a steroid hormone classically involved in the calcium metabolism and bone homeostasis. Recently, new and interesting aspects of vitamin D metabolism has been elucidated, namely the special role of the skin, the metabolic control of liver hydroxylase CYP2R1, the specificity of 1α-hydroxylase in different tissues and cell types and the genomic, non-genomic and epigenomic effects of vitamin D receptor, which will be addressed in the present review. Moreover, in the last decades, several extraskeletal effects which can be attributed to vitamin D have been shown. These beneficial effects will be here summarized, focusing on the immune system and cardiovascular system. MDPI 2020-09-08 /pmc/articles/PMC7554947/ /pubmed/32911795 http://dx.doi.org/10.3390/ijms21186573 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Saponaro, Federica
Saba, Alessandro
Zucchi, Riccardo
An Update on Vitamin D Metabolism
title An Update on Vitamin D Metabolism
title_full An Update on Vitamin D Metabolism
title_fullStr An Update on Vitamin D Metabolism
title_full_unstemmed An Update on Vitamin D Metabolism
title_short An Update on Vitamin D Metabolism
title_sort update on vitamin d metabolism
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554947/
https://www.ncbi.nlm.nih.gov/pubmed/32911795
http://dx.doi.org/10.3390/ijms21186573
work_keys_str_mv AT saponarofederica anupdateonvitamindmetabolism
AT sabaalessandro anupdateonvitamindmetabolism
AT zucchiriccardo anupdateonvitamindmetabolism
AT saponarofederica updateonvitamindmetabolism
AT sabaalessandro updateonvitamindmetabolism
AT zucchiriccardo updateonvitamindmetabolism