Isocitrate Dehydrogenase Mutations in Glioma: Genetics, Biochemistry, and Clinical Indications

Mutations in isocitrate dehydrogenase (IDH) are commonly observed in lower-grade glioma and secondary glioblastomas. IDH mutants confer a neomorphic enzyme activity that converts α-ketoglutarate to an oncometabolite D-2-hydroxyglutarate, which impacts cellular epigenetics and metabolism. IDH mutatio...

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Detalles Bibliográficos
Autores principales: Liu, Yang, Lang, Fengchao, Chou, Fu-Ju, Zaghloul, Kareem A., Yang, Chunzhang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554955/
https://www.ncbi.nlm.nih.gov/pubmed/32825279
http://dx.doi.org/10.3390/biomedicines8090294

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554955/
https://www.ncbi.nlm.nih.gov/pubmed/32825279
http://dx.doi.org/10.3390/biomedicines8090294

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