Blocking ADAM17 Function with a Monoclonal Antibody Improves Sepsis Survival in a Murine Model of Polymicrobial Sepsis

Sepsis is the culmination of hyperinflammation and immune suppression in response to severe infection. Neutrophils are critical early responders to bacterial infection but can become highly dysfunctional during sepsis and other inflammatory disorders. The transmembrane protease ADAM17 (a disintegrin...

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Detalles Bibliográficos
Autores principales: Mishra, Hemant K., Ma, Jing, Mendez, Daniel, Hullsiek, Robert, Pore, Nabendu, Walcheck, Bruce
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555020/
https://www.ncbi.nlm.nih.gov/pubmed/32932701
http://dx.doi.org/10.3390/ijms21186688

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