The Role of Cancer-Associated Fibroblasts and Extracellular Vesicles in Tumorigenesis

Extracellular vesicles (EVs) play a key role in the communication between cancer cells and stromal components of the tumor microenvironment (TME). In this context, cancer cell-derived EVs can regulate the activation of a CAF phenotype in TME cells, which can be mediated by several EV cargos (e.g., m...

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Autores principales: Shoucair, Issraa, Weber Mello, Fernanda, Jabalee, James, Maleki, Saeideh, Garnis, Cathie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555043/
https://www.ncbi.nlm.nih.gov/pubmed/32957712
http://dx.doi.org/10.3390/ijms21186837
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author Shoucair, Issraa
Weber Mello, Fernanda
Jabalee, James
Maleki, Saeideh
Garnis, Cathie
author_facet Shoucair, Issraa
Weber Mello, Fernanda
Jabalee, James
Maleki, Saeideh
Garnis, Cathie
author_sort Shoucair, Issraa
collection PubMed
description Extracellular vesicles (EVs) play a key role in the communication between cancer cells and stromal components of the tumor microenvironment (TME). In this context, cancer cell-derived EVs can regulate the activation of a CAF phenotype in TME cells, which can be mediated by several EV cargos (e.g., miRNA, proteins, mRNA and lncRNAs). On the other hand, CAF-derived EVs can mediate several processes during tumorigenesis, including tumor growth, invasion, metastasis, and therapy resistance. This review aimed to discuss the molecular aspects of EV-based cross-talk between CAFs and cancer cells during tumorigenesis, in addition to assessing the roles of EV cargo in therapy resistance and pre-metastatic niche formation.
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spelling pubmed-75550432020-10-14 The Role of Cancer-Associated Fibroblasts and Extracellular Vesicles in Tumorigenesis Shoucair, Issraa Weber Mello, Fernanda Jabalee, James Maleki, Saeideh Garnis, Cathie Int J Mol Sci Review Extracellular vesicles (EVs) play a key role in the communication between cancer cells and stromal components of the tumor microenvironment (TME). In this context, cancer cell-derived EVs can regulate the activation of a CAF phenotype in TME cells, which can be mediated by several EV cargos (e.g., miRNA, proteins, mRNA and lncRNAs). On the other hand, CAF-derived EVs can mediate several processes during tumorigenesis, including tumor growth, invasion, metastasis, and therapy resistance. This review aimed to discuss the molecular aspects of EV-based cross-talk between CAFs and cancer cells during tumorigenesis, in addition to assessing the roles of EV cargo in therapy resistance and pre-metastatic niche formation. MDPI 2020-09-17 /pmc/articles/PMC7555043/ /pubmed/32957712 http://dx.doi.org/10.3390/ijms21186837 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Shoucair, Issraa
Weber Mello, Fernanda
Jabalee, James
Maleki, Saeideh
Garnis, Cathie
The Role of Cancer-Associated Fibroblasts and Extracellular Vesicles in Tumorigenesis
title The Role of Cancer-Associated Fibroblasts and Extracellular Vesicles in Tumorigenesis
title_full The Role of Cancer-Associated Fibroblasts and Extracellular Vesicles in Tumorigenesis
title_fullStr The Role of Cancer-Associated Fibroblasts and Extracellular Vesicles in Tumorigenesis
title_full_unstemmed The Role of Cancer-Associated Fibroblasts and Extracellular Vesicles in Tumorigenesis
title_short The Role of Cancer-Associated Fibroblasts and Extracellular Vesicles in Tumorigenesis
title_sort role of cancer-associated fibroblasts and extracellular vesicles in tumorigenesis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555043/
https://www.ncbi.nlm.nih.gov/pubmed/32957712
http://dx.doi.org/10.3390/ijms21186837
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