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The Role of Epac in Cancer Progression

Cancer continues to be a prime contributor to global mortality. Despite tremendous research efforts and major advances in cancer therapy, much remains to be learned about the underlying molecular mechanisms of this debilitating disease. A better understanding of the key signaling events driving the...

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Autores principales: Wehbe, Nadine, Slika, Hasan, Mesmar, Joelle, Nasser, Suzanne A., Pintus, Gianfranco, Baydoun, Serine, Badran, Adnan, Kobeissy, Firas, Eid, Ali H., Baydoun, Elias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555121/
https://www.ncbi.nlm.nih.gov/pubmed/32899451
http://dx.doi.org/10.3390/ijms21186489
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author Wehbe, Nadine
Slika, Hasan
Mesmar, Joelle
Nasser, Suzanne A.
Pintus, Gianfranco
Baydoun, Serine
Badran, Adnan
Kobeissy, Firas
Eid, Ali H.
Baydoun, Elias
author_facet Wehbe, Nadine
Slika, Hasan
Mesmar, Joelle
Nasser, Suzanne A.
Pintus, Gianfranco
Baydoun, Serine
Badran, Adnan
Kobeissy, Firas
Eid, Ali H.
Baydoun, Elias
author_sort Wehbe, Nadine
collection PubMed
description Cancer continues to be a prime contributor to global mortality. Despite tremendous research efforts and major advances in cancer therapy, much remains to be learned about the underlying molecular mechanisms of this debilitating disease. A better understanding of the key signaling events driving the malignant phenotype of cancer cells may help identify new pharmaco-targets. Cyclic adenosine 3′,5′-monophosphate (cAMP) modulates a plethora of biological processes, including those that are characteristic of malignant cells. Over the years, most cAMP-mediated actions were attributed to the activity of its effector protein kinase A (PKA). However, studies have revealed an important role for the exchange protein activated by cAMP (Epac) as another effector mediating the actions of cAMP. In cancer, Epac appears to have a dual role in regulating cellular processes that are essential for carcinogenesis. In addition, the development of Epac modulators offered new routes to further explore the role of this cAMP effector and its downstream pathways in cancer. In this review, the potentials of Epac as an attractive target in the fight against cancer are depicted. Additionally, the role of Epac in cancer progression, namely its effect on cancer cell proliferation, migration/metastasis, and apoptosis, with the possible interaction of reactive oxygen species (ROS) in these phenomena, is discussed with emphasis on the underlying mechanisms and pathways.
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spelling pubmed-75551212020-10-14 The Role of Epac in Cancer Progression Wehbe, Nadine Slika, Hasan Mesmar, Joelle Nasser, Suzanne A. Pintus, Gianfranco Baydoun, Serine Badran, Adnan Kobeissy, Firas Eid, Ali H. Baydoun, Elias Int J Mol Sci Review Cancer continues to be a prime contributor to global mortality. Despite tremendous research efforts and major advances in cancer therapy, much remains to be learned about the underlying molecular mechanisms of this debilitating disease. A better understanding of the key signaling events driving the malignant phenotype of cancer cells may help identify new pharmaco-targets. Cyclic adenosine 3′,5′-monophosphate (cAMP) modulates a plethora of biological processes, including those that are characteristic of malignant cells. Over the years, most cAMP-mediated actions were attributed to the activity of its effector protein kinase A (PKA). However, studies have revealed an important role for the exchange protein activated by cAMP (Epac) as another effector mediating the actions of cAMP. In cancer, Epac appears to have a dual role in regulating cellular processes that are essential for carcinogenesis. In addition, the development of Epac modulators offered new routes to further explore the role of this cAMP effector and its downstream pathways in cancer. In this review, the potentials of Epac as an attractive target in the fight against cancer are depicted. Additionally, the role of Epac in cancer progression, namely its effect on cancer cell proliferation, migration/metastasis, and apoptosis, with the possible interaction of reactive oxygen species (ROS) in these phenomena, is discussed with emphasis on the underlying mechanisms and pathways. MDPI 2020-09-05 /pmc/articles/PMC7555121/ /pubmed/32899451 http://dx.doi.org/10.3390/ijms21186489 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wehbe, Nadine
Slika, Hasan
Mesmar, Joelle
Nasser, Suzanne A.
Pintus, Gianfranco
Baydoun, Serine
Badran, Adnan
Kobeissy, Firas
Eid, Ali H.
Baydoun, Elias
The Role of Epac in Cancer Progression
title The Role of Epac in Cancer Progression
title_full The Role of Epac in Cancer Progression
title_fullStr The Role of Epac in Cancer Progression
title_full_unstemmed The Role of Epac in Cancer Progression
title_short The Role of Epac in Cancer Progression
title_sort role of epac in cancer progression
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555121/
https://www.ncbi.nlm.nih.gov/pubmed/32899451
http://dx.doi.org/10.3390/ijms21186489
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