Cargando…

MuRF1/TRIM63, Master Regulator of Muscle Mass

The E3 ubiquitin ligase MuRF1/TRIM63 was identified 20 years ago and suspected to play important roles during skeletal muscle atrophy. Since then, numerous studies have been conducted to decipher the roles, molecular mechanisms and regulation of this enzyme. This revealed that MuRF1 is an important...

Descripción completa

Detalles Bibliográficos
Autores principales:	Peris-Moreno, Dulce, Taillandier, Daniel, Polge, Cécile
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555135/ https://www.ncbi.nlm.nih.gov/pubmed/32933049 http://dx.doi.org/10.3390/ijms21186663

Ejemplares similares

UBE2L3, a Partner of MuRF1/TRIM63, Is Involved in the Degradation of Myofibrillar Actin and Myosin
por: Peris-Moreno, Dulce, et al.
Publicado: (2021)

A muscle‐specific MuRF1‐E2 network requires stabilization of MuRF1‐E2 complexes by telethonin, a newly identified substrate
por: Polge, Cécile, et al.
Publicado: (2017)

Cooperative control of striated muscle mass and metabolism by MuRF1 and MuRF2
por: Witt, Christian C, et al.
Publicado: (2008)

TRIM63 (MuRF-1) gene polymorphism is associated with biomarkers of exercise-induced muscle damage
por: Baumert, P., et al.
Publicado: (2018)

Rare Variants in Genes Encoding MuRF1 and MuRF2 Are Modifiers of Hypertrophic Cardiomyopathy
por: Su, Ming, et al.
Publicado: (2014)

Regulation of Glucose Metabolism by MuRF1 and Treatment of Myopathy in Diabetic Mice with Small Molecules Targeting MuRF1
por: Labeit, Siegfried, et al.
Publicado: (2021)

Modulation of Muscle Atrophy, Fatigue and MLC Phosphorylation by MuRF1 as Indicated by Hindlimb Suspension Studies on MuRF1-KO Mice
por: Labeit, Siegfried, et al.
Publicado: (2010)

Expression of MuRF1 or MuRF2 is essential for the induction of skeletal muscle atrophy and dysfunction in a murine pulmonary hypertension model
por: Nguyen, Thanh, et al.
Publicado: (2020)

Expanding the MuRF1 Universe with Quantitative Ubiquitylomics
por: Goodman, Craig A, et al.
Publicado: (2021)

Ubiquitin Ligases at the Heart of Skeletal Muscle Atrophy Control
por: Peris-Moreno, Dulce, et al.
Publicado: (2021)

Small‐molecule‐mediated chemical knock‐down of MuRF1/MuRF2 and attenuation of diaphragm dysfunction in chronic heart failure
por: Adams, Volker, et al.
Publicado: (2019)

Stable atrogin-1 (Fbxo32) and MuRF1 (Trim63) gene expression is involved in the protective mechanism in soleus muscle of hibernating Daurian ground squirrels (Spermophilus dauricus)
por: Dang, Kai, et al.
Publicado: (2016)

Noninvasive Imaging of In Vivo MuRF1 Expression during Muscle Atrophy
por: Li, Wei, et al.
Publicado: (2014)

Identification of the MuRF1 Skeletal Muscle Ubiquitylome Through Quantitative Proteomics
por: Baehr, Leslie M, et al.
Publicado: (2021)

Molecular basis for the fold organization and sarcomeric targeting of the muscle atrogin MuRF1
por: Franke, Barbara, et al.
Publicado: (2014)

Correction: Stable atrogin-1 (Fbxo32) and MuRF1 (Trim63) gene expression is involved in the protective mechanism in soleus muscle of hibernating Daurian ground squirrels (Spermophilus dauricus)
por: Dang, Kai, et al.
Publicado: (2022)

Mice overexpressing growth hormone exhibit increased skeletal muscle myostatin and MuRF1 with attenuation of muscle mass
por: Consitt, Leslie A., et al.
Publicado: (2017)

Removal of MuRF1 Increases Muscle Mass in Nemaline Myopathy Models, but Does Not Provide Functional Benefits
por: Lindqvist, Johan, et al.
Publicado: (2022)

Exploration of the TRIM Fold of MuRF1 Using EPR Reveals a Canonical Antiparallel Structure and Extended COS-Box
por: Stevens, Michael, et al.
Publicado: (2019)

MuRF-1 and Atrogin-1 Protein Expression and Quadriceps Fiber Size and Muscle Mass in Stable Patients with COPD
por: Natanek, Samantha A., et al.
Publicado: (2013)

Muscle hypertrophy is associated with increases in proteasome activity that is independent of MuRF1 and MAFbx expression
por: Baehr, Leslie M., et al.
Publicado: (2014)

Imoxin attenuates LPS‐induced inflammation and MuRF1 expression in mouse skeletal muscle
por: Valentine, Rudy J., et al.
Publicado: (2018)

Sabinene Prevents Skeletal Muscle Atrophy by Inhibiting the MAPK–MuRF-1 Pathway in Rats
por: Ryu, Yunkyoung, et al.
Publicado: (2019)

During muscle atrophy, thick, but not thin, filament components are degraded by MuRF1-dependent ubiquitylation
por: Cohen, Shenhav, et al.
Publicado: (2009)

Small‐molecule inhibition of MuRF1 attenuates skeletal muscle atrophy and dysfunction in cardiac cachexia
por: Bowen, Thomas Scott, et al.
Publicado: (2017)

Skeletal Muscle Stromal Cells Derived From MuRF1 Knockout Mice Are Resistant to Adipogenesis
por: Norman, Jennifer Elise, et al.
Publicado: (2021)

The Effects of Diet Induced Obesity (DIO) on Skeletal Muscle Transcription in MuRF1 KO Mice
por: Marshall, Andrea Gail, et al.
Publicado: (2021)

Regulation of nicotinic acetylcholine receptor turnover by MuRF1 connects muscle activity to endo/lysosomal and atrophy pathways
por: Rudolf, Rüdiger, et al.
Publicado: (2012)

The Calcineurin-FoxO-MuRF1 signaling pathway regulates myofibril integrity in cardiomyocytes
por: Shimizu, Hirohito, et al.
Publicado: (2017)

The Posterior Cricoarytenoid Muscle Is Spared from MuRF1-Mediated Muscle Atrophy in Mice with Acute Lung Injury
por: Files, D. Clark, et al.
Publicado: (2014)

Differences in the Role of HDACs 4 and 5 in the Modulation of Processes Regulating MAFbx and MuRF1 Expression during Muscle Unloading
por: Mochalova, Ekaterina P., et al.
Publicado: (2020)

Excessive glucocorticoid-induced muscle MuRF1 overexpression is independent of Akt/FoXO1 pathway
por: Wang, Xiao Juan, et al.
Publicado: (2017)

Muscle RING-finger protein-1 (MuRF1) functions and cellular localization are regulated by SUMO1 post-translational modification
por: Heras, Gabriel, et al.
Publicado: (2018)

The E3 ligase MuRF2 plays a key role in the functional capacity of skeletal muscle fibroblasts
por: Silvestre, J.G., et al.
Publicado: (2019)

Titin kinase is an inactive pseudokinase scaffold that supports MuRF1 recruitment to the sarcomeric M-line
por: Bogomolovas, Julijus, et al.
Publicado: (2014)

Blocking muscle wasting via deletion of the muscle-specific E3 ligase MuRF1 impedes pancreatic tumor growth
por: Neyroud, Daria, et al.
Publicado: (2023)

Metformin attenuates angiotensin II-induced cardiomyocyte hypertrophy by upregulating the MuRF1 and MAFbx pathway
por: Du, Fawang, et al.
Publicado: (2021)

Small-Molecule Inhibition of MuRF1 Prevents Early Disuse-Induced Diaphragmatic Dysfunction and Atrophy
por: Ribeiro, Fernando, et al.
Publicado: (2023)

Blocking muscle wasting via deletion of the muscle specific E3 ubiquitin ligase MuRF1 impedes pancreatic tumor growth
por: Neyroud, Daria, et al.
Publicado: (2023)

A Single Bout of Ultra-Endurance Exercise Reveals Early Signs of Muscle Aging in Master Athletes
por: Coudy-Gandilhon, Cécile, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_88s5e8uen9e4kaqreforh01u84