Cargando…

Mouse Ataxin-2 Expansion Downregulates CamKII and Other Calcium Signaling Factors, Impairing Granule—Purkinje Neuron Synaptic Strength

Spinocerebellar ataxia type 2 (SCA2) is caused by polyglutamine expansion in Ataxin-2 (ATXN2). This factor binds RNA/proteins to modify metabolism after stress, and to control calcium (Ca(2+)) homeostasis after stimuli. Cerebellar ataxias and corticospinal motor neuron degeneration are determined by...

Descripción completa

Detalles Bibliográficos
Autores principales:	Arsović, Aleksandar, Halbach, Melanie Vanessa, Canet-Pons, Júlia, Esen-Sehir, Dilhan, Döring, Claudia, Freudenberg, Florian, Czechowska, Nicoletta, Seidel, Kay, Baader, Stephan L., Gispert, Suzana, Sen, Nesli-Ece, Auburger, Georg
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555182/ https://www.ncbi.nlm.nih.gov/pubmed/32932600 http://dx.doi.org/10.3390/ijms21186673

Ejemplares similares

In Human and Mouse Spino-Cerebellar Tissue, Ataxin-2 Expansion Affects Ceramide-Sphingomyelin Metabolism
por: Sen, Nesli-Ece, et al.
Publicado: (2019)

PINK1 and Ataxin-2 as modifiers of growth
por: Sen, Nesli E., et al.
Publicado: (2017)

Dishevelled activates Ca(2+) flux, PKC, and CamKII in vertebrate embryos
por: Sheldahl, Laird C., et al.
Publicado: (2003)

PTBP-dependent PSD-95 and CamKIIα alternative splicing in the lens
por: Frederikse, Peter, et al.
Publicado: (2014)

SerThr-PhosphoProteome of Brain from Aged PINK1-KO+A53T-SNCA Mice Reveals pT1928-MAP1B and pS3781-ANK2 Deficits, as Hub between Autophagy and Synapse Changes
por: Auburger, Georg, et al.
Publicado: (2019)

CMTX1 patients’ cells present genomic instability corrected by CamKII inhibitors
por: Saleh, Mones, et al.
Publicado: (2015)

Systematic Surveys of Iron Homeostasis Mechanisms Reveal Ferritin Superfamily and Nucleotide Surveillance Regulation to be Modified by PINK1 Absence
por: Key, Jana, et al.
Publicado: (2020)

Erratum to: CMTX1 patients’ cells present genomic instability corrected by CamKII inhibitors
por: Mones, Saleh, et al.
Publicado: (2016)

Genetic ablation of ataxin-2 increases several global translation factors in their transcript abundance but decreases translation rate
por: Fittschen, M., et al.
Publicado: (2015)

Bisphenol A induces coronary endothelial cell necroptosis by activating RIP3/CamKII dependent pathway
por: Reventun, P., et al.
Publicado: (2020)

Mid-Gestation lethality of Atxn2l-Ablated Mice
por: Key, Jana, et al.
Publicado: (2020)

Distinct functionality of dishevelled isoforms on Ca(2+)/calmodulin-dependent protein kinase 2 (CamKII) in Xenopus gastrulation
por: Gentzel, Marc, et al.
Publicado: (2015)

Acute Chemogenetic Activation of CamKIIα-Positive Forebrain Excitatory Neurons Regulates Anxiety-Like Behaviour in Mice
por: Salvi, Sonali S., et al.
Publicado: (2019)

Transcriptional Responses of In Vivo Praziquantel Exposure in Schistosomes Identifies a Functional Role for Calcium Signalling Pathway Member CamKII
por: You, Hong, et al.
Publicado: (2013)

TR-FRET-Based Immunoassay to Measure Ataxin-2 as a Target Engagement Marker in Spinocerebellar Ataxia Type 2
por: Bux, Jessica, et al.
Publicado: (2023)

Activation of CamKIIα expressing neurons on ventrolateral periaqueductal gray improves behavioral hypersensitivity and thalamic discharge in a trigeminal neuralgia rat model
por: Elina, K. C., et al.
Publicado: (2021)

CamKII inhibitors reduce mitotic instability, connexon anomalies and progression of the in vivo behavioral phenotype in transgenic animals expressing a mutated Gjb1 gene
por: Mones, Saleh, et al.
Publicado: (2014)

Investigations of brain-wide functional and structural networks of dopaminergic and CamKIIα-positive neurons in VTA with DREADD-fMRI and neurotropic virus tracing technologies
por: Zheng, Ning, et al.
Publicado: (2023)

Atxn2 Knockout and CAG42-Knock-in Cerebellum Shows Similarly Dysregulated Expression in Calcium Homeostasis Pathway
por: Halbach, Melanie Vanessa, et al.
Publicado: (2016)

A novel and atypical NF-KB pro-inflammatory program regulated by a CamKII-proteasome axis is involved in the early activation of Muller glia by high glucose
por: Sbardella, Diego, et al.
Publicado: (2022)

Both Ubiquitin Ligases FBXW8 and PARK2 Are Sequestrated into Insolubility by ATXN2 PolyQ Expansions, but Only FBXW8 Expression Is Dysregulated
por: Halbach, Melanie Vanessa, et al.
Publicado: (2015)

Increased presence of nuclear DNAJA3 and upregulation of cytosolic STAT1 and of nucleic acid sensors trigger innate immunity in the ClpP-null mouse
por: Maletzko, Antonia, et al.
Publicado: (2021)

Methyl-Arginine Profile of Brain from Aged PINK1-KO+A53T-SNCA Mice Suggests Altered Mitochondrial Biogenesis
por: Auburger, Georg, et al.
Publicado: (2016)

The Bacterial ClpXP-ClpB Family Is Enriched with RNA-Binding Protein Complexes
por: Auburger, Georg, et al.
Publicado: (2022)

Binding of Filamentous Actin to CaMKII as Potential Regulation Mechanism of Bidirectional Synaptic Plasticity by β CaMKII in Cerebellar Purkinje Cells
por: Pinto, Thiago M., et al.
Publicado: (2020)

Ataxin-2 Modulates the Levels of Grb2 and Src but Not Ras Signaling
por: Drost, Jessica, et al.
Publicado: (2013)

βCaMKII regulates bidirectional long-term plasticity in cerebellar Purkinje cells by a CaMKII/PP2B switch mechanism
por: Pinto, Thiago M, et al.
Publicado: (2014)

Juu kii' Palabra nuestra : hacia la escritura del chinanteco de la sierra norte de Oaxaca
por: Hernández López, Pedro
Publicado: (2002)

Filamentous actin binding enables βCaMKII to regulate bidirectional plasticity in cerebellar Purkinje cells
por: Pinto, Thiago M, et al.
Publicado: (2013)

Striatal Dopamine Transmission Is Subtly Modified in Human A53Tα-Synuclein Overexpressing Mice
por: Platt, Nicola J., et al.
Publicado: (2012)

LBL experiments T2K, T2KII, HyperK, HyperKK
por: di Lodovico, Francesca, et al.
Publicado: (2018)

Cerebrospinal Fluid Biomarkers for Kii Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex
por: Nakayama, Yui, et al.
Publicado: (2013)

FOX-2 Dependent Splicing of Ataxin-2 Transcript Is Affected by Ataxin-1 Overexpression
por: Welzel, Franziska, et al.
Publicado: (2012)

Therapeutic reduction of ataxin 2 extends lifespan and reduces pathology in TDP-43 mice
por: Becker, Lindsay A., et al.
Publicado: (2017)

Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation
por: Torres-Odio, Sylvia, et al.
Publicado: (2017)

Neuropsychological study of amyotrophic lateral sclerosis and parkinsonism-dementia complex in Kii peninsula, Japan
por: Shindo, Akihiro, et al.
Publicado: (2014)

Tau imaging detects distinctive distribution of tau pathology in ALS/PDC on the Kii Peninsula
por: Shinotoh, Hitoshi, et al.
Publicado: (2019)

Hippocampal overexpression of NOS1AP promotes endophenotypes related to mental disorders
por: Freudenberg, Florian, et al.
Publicado: (2021)

Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS
por: Elden, Andrew C., et al.
Publicado: (2010)

Alpha-synuclein deficiency leads to increased glyoxalase I expression and glycation stress
por: Kurz, Alexander, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_09isui12rlmo14gvtslio7i3kp