Cargando…

Potent Small-Molecule Inhibitors Targeting Acetylated Microtubules as Anticancer Agents Against Triple-Negative Breast Cancer

Microtubules are one of the major targets for anticancer drugs because of their role in cell proliferation and migration. However, as anticancer drugs targeting microtubules have side effects, including the death of normal cells, it is necessary to develop anticancer agents that can target microtubu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kwon, Ahreum, Lee, Gwi Bin, Park, Taein, Lee, Jung Hoon, Ko, Panseon, You, Eunae, Ahn, Jin Hee, Eom, Soo Hyun, Rhee, Sangmyung, Song, Woo Keun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555225/ https://www.ncbi.nlm.nih.gov/pubmed/32917017 http://dx.doi.org/10.3390/biomedicines8090338

Ejemplares similares

Microtubule Acetylation-Specific Inhibitors Induce Cell Death and Mitotic Arrest via JNK/AP-1 Activation in Triple-Negative Breast Cancer Cells
por: Ahn, Suyeon, et al.
Publicado: (2023)

DDR2 controls the epithelial-mesenchymal-transition-related gene expression via c-Myb acetylation upon matrix stiffening
por: Kim, Daehwan, et al.
Publicado: (2017)

Microtubule Acetylation Controls MDA-MB-231 Breast Cancer Cell Invasion through the Modulation of Endoplasmic Reticulum Stress
por: Ko, Panseon, et al.
Publicado: (2021)

mDia1 regulates breast cancer invasion by controlling membrane type 1-matrix metalloproteinase localization
por: Kim, Daehwan, et al.
Publicado: (2016)

Extracellular Matrix Rigidity-dependent Sphingosine-1-phosphate Secretion Regulates Metastatic Cancer Cell Invasion and Adhesion
por: Ko, Panseon, et al.
Publicado: (2016)

Shwachman-Bodian-Diamond syndrome protein desensitizes breast cancer cells to apoptosis in stiff matrices by repressing the caspase 8-mediated pathway
por: Lee, Jieun, et al.
Publicado: (2019)

Tumor-derived miR-130b-3p induces cancer-associated fibroblast activation by targeting SPIN90 in luminal A breast cancer
por: Ahn, Suyeon, et al.
Publicado: (2022)

Biological Evaluation of Noscapine analogues as Potent and Microtubule-Targeted Anticancer Agents
por: Tomar, Vartika, et al.
Publicado: (2019)

Casein kinase 2 promotes the TGF-β-induced activation of α-tubulin acetyltransferase 1 in fibroblasts cultured on a soft matrix
por: You, Eunae, et al.
Publicado: (2022)

Small molecules targeting Pin1 as potent anticancer drugs
por: Zhang, Jing, et al.
Publicado: (2023)

Acetylated microtubules let the ER slide
por: Short, Ben
Publicado: (2010)

Microtubule acetylation dyshomeostasis in Parkinson’s disease
por: Naren, Padmashri, et al.
Publicado: (2023)

Microtubule polyglutamylation and acetylation drive microtubule dynamics critical for platelet formation
por: van Dijk, Juliette, et al.
Publicado: (2018)

Acetylated microtubules are required for fusion of autophagosomes with lysosomes
por: Xie, Rui, et al.
Publicado: (2010)

Modulation Of Microtubule Acetylation By The Interplay Of TPPP/p25, SIRT2 And New Anticancer Agents With Anti-SIRT2 Potency
por: Szabó, Adél, et al.
Publicado: (2017)

The Ability to Induce Microtubule Acetylation Is a General Feature of Formin Proteins
por: Thurston, Susan F., et al.
Publicado: (2012)

The BET bromodomain inhibitor exerts the most potent synergistic anticancer effects with quinone-containing compounds and anti-microtubule drugs
por: Liu, Pei Y., et al.
Publicado: (2016)

Copper-Plumbagin Complex Produces Potent Anticancer Effects by Depolymerizing Microtubules and Inducing Reactive Oxygen Species and DNA Damage
por: Mukherjee, Sandipan, et al.
Publicado: (2023)

Beta-Pix-dynamin 2 complex promotes colorectal cancer progression by facilitating membrane dynamics
por: Keum, Seula, et al.
Publicado: (2021)

Synthesis and Biological Evaluation of Novel Triple-Modified Colchicine Derivatives as Potent Tubulin-Targeting Anticancer Agents
por: Majcher, Urszula, et al.
Publicado: (2018)

P21-activated kinase 1: convergence point in PDGF- and LPA-stimulated collagen matrix contraction by human fibroblasts
por: Rhee, Sangmyung, et al.
Publicado: (2006)

Effects of α-tubulin acetylation on microtubule structure and stability
por: Eshun-Wilson, Lisa, et al.
Publicado: (2019)

Calpain-6, a Target Molecule of Glucocorticoids, Regulates Osteoclastic Bone Resorption via Cytoskeletal Organization and Microtubule Acetylation
por: Hong, Jung Min, et al.
Publicado: (2011)

Pseudopyronine B: A Potent Antimicrobial and Anticancer Molecule Isolated from a Pseudomonas mosselii
por: Nishanth Kumar, S., et al.
Publicado: (2016)

The Design and Development of Potent Small Molecules as Anticancer Agents Targeting EGFR TK and Tubulin Polymerization
por: Ihmaid, Saleh, et al.
Publicado: (2018)

Targeting BET Proteins With a PROTAC Molecule Elicits Potent Anticancer Activity in HCC Cells
por: Zhang, Huapeng, et al.
Publicado: (2020)

Triple action Pt(iv) derivatives of cisplatin: a new class of potent anticancer agents that overcome resistance
por: Petruzzella, Emanuele, et al.
Publicado: (2018)

The acetylation of alpha-tubulin and its relationship to the assembly and disassembly of microtubules
Publicado: (1986)

Microtubules containing acetylated alpha-tubulin in mammalian cells in culture
Publicado: (1987)

Effects of tubulin acetylation and tubulin acetyltransferase binding on microtubule structure
por: Howes, Stuart C., et al.
Publicado: (2014)

Increased acetylation of microtubules rescues human tau-induced microtubule defects and neuromuscular junction abnormalities in Drosophila
por: Mao, Chuan-Xi, et al.
Publicado: (2017)

Anticancer mechanism of 7-α-hydroxyfrullanolide on microtubules and computational prediction of its target binding in triple-negative breast cancer cells
por: Chimplee, Siriphorn, et al.
Publicado: (2022)

Retraction: Pseudopyronine B: A Potent Antimicrobial and Anticancer Molecule Isolated from a Pseudomonas mosselii
Publicado: (2017)

Inhibitor of DNA binding 2 (Id2) mediates microtubule polymerization in the brain by regulating αK40 acetylation of α-tubulin
por: Yun, Taegwan, et al.
Publicado: (2021)

ER sliding dynamics and ER–mitochondrial contacts occur on acetylated microtubules
por: Friedman, Jonathan R., et al.
Publicado: (2010)

Tubulin acetylation protects long-lived microtubules against mechanical aging
por: Portran, Didier, et al.
Publicado: (2017)

MYO1F regulates antifungal immunity by regulating acetylation of microtubules
por: Sun, Wanwei, et al.
Publicado: (2021)

Branched Actin Maintains Acetylated Microtubule Network in the Early Secretory Pathway
por: Yoshimura, Azumi, et al.
Publicado: (2021)

Feasibility of low dose chest CT for virtual bronchoscopy navigation in a porcine model
por: Kim, Insu, et al.
Publicado: (2019)

Correction to: Inhibitor of DNA binding 2 (Id2) mediates microtubule polymerization in the brain by regulating αK40 acetylation of α-tubulin
por: Yun, Taegwan, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_7kr4q1el87t3lofne9cdglkrq0