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Habitual Aerobic Exercise Diminishes the Effects of Sarcopenia in Senescence-Accelerated Mice Prone8 Model

Loss of muscle mass and strength are progressing with aging. Exercise is a beneficial method to prevent physical dysfunction, and habitual exercise can improve the muscle quality. Therefore, we evaluated the effects of long-term habitual exercise’s impact on sarcopenia utilizing the senescence-accel...

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Autores principales: Aoki, Kai, Konno, Masaki, Honda, Katsunari, Abe, Takuya, Nagata, Takeshi, Takehara, Masaaki, Sugasawa, Takehito, Takekoshi, Kazuhiro, Ohmori, Hajime
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555272/
https://www.ncbi.nlm.nih.gov/pubmed/32916898
http://dx.doi.org/10.3390/geriatrics5030048
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author Aoki, Kai
Konno, Masaki
Honda, Katsunari
Abe, Takuya
Nagata, Takeshi
Takehara, Masaaki
Sugasawa, Takehito
Takekoshi, Kazuhiro
Ohmori, Hajime
author_facet Aoki, Kai
Konno, Masaki
Honda, Katsunari
Abe, Takuya
Nagata, Takeshi
Takehara, Masaaki
Sugasawa, Takehito
Takekoshi, Kazuhiro
Ohmori, Hajime
author_sort Aoki, Kai
collection PubMed
description Loss of muscle mass and strength are progressing with aging. Exercise is a beneficial method to prevent physical dysfunction, and habitual exercise can improve the muscle quality. Therefore, we evaluated the effects of long-term habitual exercise’s impact on sarcopenia utilizing the senescence-accelerated mice prone8 (SAMP8) model. Notably, 27 w SAMP8 were used in this study. Mice were classified into 28 (28 w) and 44 weeks old. The 44-week group was divided into the sedentary group (44 w) and a group exercising for 16 weeks (44 w + Ex). The 44 w + Ex performed habitual exercise from 28 to 44 weeks. Additionally, grip strength tests were performed with mice aged 28 and 44 weeks. Muscles were harvested and measured muscle weight at 44 w. Gastrocnemius decreased in 44 w, but was unchanged in 44 w + Ex. There was a trend for lower muscle grip strength in the 44 w group, but there was no change in 44 w + Ex. The phosphorylation levels of Akt and p70S6K as a protein synthesis marker were decreased in 44 w. Cytochrome c oxidase subunit IV (CoxIV) mRNA and protein levels decreased in 44 w. These results suggested that long-term habitual exercise attenuates muscle mass and strength decline, possibly through maintenance of muscle protein synthesis and mitochondrial maintenance.
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spelling pubmed-75552722020-10-19 Habitual Aerobic Exercise Diminishes the Effects of Sarcopenia in Senescence-Accelerated Mice Prone8 Model Aoki, Kai Konno, Masaki Honda, Katsunari Abe, Takuya Nagata, Takeshi Takehara, Masaaki Sugasawa, Takehito Takekoshi, Kazuhiro Ohmori, Hajime Geriatrics (Basel) Article Loss of muscle mass and strength are progressing with aging. Exercise is a beneficial method to prevent physical dysfunction, and habitual exercise can improve the muscle quality. Therefore, we evaluated the effects of long-term habitual exercise’s impact on sarcopenia utilizing the senescence-accelerated mice prone8 (SAMP8) model. Notably, 27 w SAMP8 were used in this study. Mice were classified into 28 (28 w) and 44 weeks old. The 44-week group was divided into the sedentary group (44 w) and a group exercising for 16 weeks (44 w + Ex). The 44 w + Ex performed habitual exercise from 28 to 44 weeks. Additionally, grip strength tests were performed with mice aged 28 and 44 weeks. Muscles were harvested and measured muscle weight at 44 w. Gastrocnemius decreased in 44 w, but was unchanged in 44 w + Ex. There was a trend for lower muscle grip strength in the 44 w group, but there was no change in 44 w + Ex. The phosphorylation levels of Akt and p70S6K as a protein synthesis marker were decreased in 44 w. Cytochrome c oxidase subunit IV (CoxIV) mRNA and protein levels decreased in 44 w. These results suggested that long-term habitual exercise attenuates muscle mass and strength decline, possibly through maintenance of muscle protein synthesis and mitochondrial maintenance. MDPI 2020-09-09 /pmc/articles/PMC7555272/ /pubmed/32916898 http://dx.doi.org/10.3390/geriatrics5030048 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Aoki, Kai
Konno, Masaki
Honda, Katsunari
Abe, Takuya
Nagata, Takeshi
Takehara, Masaaki
Sugasawa, Takehito
Takekoshi, Kazuhiro
Ohmori, Hajime
Habitual Aerobic Exercise Diminishes the Effects of Sarcopenia in Senescence-Accelerated Mice Prone8 Model
title Habitual Aerobic Exercise Diminishes the Effects of Sarcopenia in Senescence-Accelerated Mice Prone8 Model
title_full Habitual Aerobic Exercise Diminishes the Effects of Sarcopenia in Senescence-Accelerated Mice Prone8 Model
title_fullStr Habitual Aerobic Exercise Diminishes the Effects of Sarcopenia in Senescence-Accelerated Mice Prone8 Model
title_full_unstemmed Habitual Aerobic Exercise Diminishes the Effects of Sarcopenia in Senescence-Accelerated Mice Prone8 Model
title_short Habitual Aerobic Exercise Diminishes the Effects of Sarcopenia in Senescence-Accelerated Mice Prone8 Model
title_sort habitual aerobic exercise diminishes the effects of sarcopenia in senescence-accelerated mice prone8 model
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555272/
https://www.ncbi.nlm.nih.gov/pubmed/32916898
http://dx.doi.org/10.3390/geriatrics5030048
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