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Plant Extracts as Possible Agents for Sequela of Cancer Therapies and Cachexia

Cancer is a leading cause of the death worldwide. Since the National Cancer Act in 1971, various cancer treatments were developed including chemotherapy, surgery, radiation therapy and so forth. However, sequela of such cancer therapies and cachexia are problem to the patients. The primary mechanism...

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Autores principales: Lee, Jinjoo, Jeong, Myung In, Kim, Hyo-Rim, Park, Hyejin, Moon, Won-Kyoung, Kim, Bonglee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555300/
https://www.ncbi.nlm.nih.gov/pubmed/32906727
http://dx.doi.org/10.3390/antiox9090836
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author Lee, Jinjoo
Jeong, Myung In
Kim, Hyo-Rim
Park, Hyejin
Moon, Won-Kyoung
Kim, Bonglee
author_facet Lee, Jinjoo
Jeong, Myung In
Kim, Hyo-Rim
Park, Hyejin
Moon, Won-Kyoung
Kim, Bonglee
author_sort Lee, Jinjoo
collection PubMed
description Cancer is a leading cause of the death worldwide. Since the National Cancer Act in 1971, various cancer treatments were developed including chemotherapy, surgery, radiation therapy and so forth. However, sequela of such cancer therapies and cachexia are problem to the patients. The primary mechanism of cancer sequela and cachexia is closely related to reactive oxygen species (ROS) and inflammation. As antioxidant properties of numerous plant extracts have been widely reported, plant-derived drugs may have efficacy on managing the sequela and cachexia. In this study, recent seventy-four studies regarding plant extracts showing ability to manage the sequela and cachexia were reviewed. Some plant-derived antioxidants inhibited cancer proliferation and inflammation after surgery and others prevented chemotherapy-induced normal cell apoptosis. Also, there are plant extracts that suppressed radiation-induced oxidative stress and cell damage by elevation of glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and regulation of B-cell lymphoma 2 (BcL-2) and Bcl-2-associated X protein (Bax). Cachexia was also alleviated by inhibition of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1) by plant extracts. This review focuses on the potential of plant extracts as great therapeutic agents by controlling oxidative stress and inflammation.
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spelling pubmed-75553002020-10-19 Plant Extracts as Possible Agents for Sequela of Cancer Therapies and Cachexia Lee, Jinjoo Jeong, Myung In Kim, Hyo-Rim Park, Hyejin Moon, Won-Kyoung Kim, Bonglee Antioxidants (Basel) Review Cancer is a leading cause of the death worldwide. Since the National Cancer Act in 1971, various cancer treatments were developed including chemotherapy, surgery, radiation therapy and so forth. However, sequela of such cancer therapies and cachexia are problem to the patients. The primary mechanism of cancer sequela and cachexia is closely related to reactive oxygen species (ROS) and inflammation. As antioxidant properties of numerous plant extracts have been widely reported, plant-derived drugs may have efficacy on managing the sequela and cachexia. In this study, recent seventy-four studies regarding plant extracts showing ability to manage the sequela and cachexia were reviewed. Some plant-derived antioxidants inhibited cancer proliferation and inflammation after surgery and others prevented chemotherapy-induced normal cell apoptosis. Also, there are plant extracts that suppressed radiation-induced oxidative stress and cell damage by elevation of glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and regulation of B-cell lymphoma 2 (BcL-2) and Bcl-2-associated X protein (Bax). Cachexia was also alleviated by inhibition of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1) by plant extracts. This review focuses on the potential of plant extracts as great therapeutic agents by controlling oxidative stress and inflammation. MDPI 2020-09-07 /pmc/articles/PMC7555300/ /pubmed/32906727 http://dx.doi.org/10.3390/antiox9090836 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Lee, Jinjoo
Jeong, Myung In
Kim, Hyo-Rim
Park, Hyejin
Moon, Won-Kyoung
Kim, Bonglee
Plant Extracts as Possible Agents for Sequela of Cancer Therapies and Cachexia
title Plant Extracts as Possible Agents for Sequela of Cancer Therapies and Cachexia
title_full Plant Extracts as Possible Agents for Sequela of Cancer Therapies and Cachexia
title_fullStr Plant Extracts as Possible Agents for Sequela of Cancer Therapies and Cachexia
title_full_unstemmed Plant Extracts as Possible Agents for Sequela of Cancer Therapies and Cachexia
title_short Plant Extracts as Possible Agents for Sequela of Cancer Therapies and Cachexia
title_sort plant extracts as possible agents for sequela of cancer therapies and cachexia
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555300/
https://www.ncbi.nlm.nih.gov/pubmed/32906727
http://dx.doi.org/10.3390/antiox9090836
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