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MicroRNAs Responding to Space Radiation

High-energy and high-atom-number (HZE) space radiation poses an inevitable potential threat to astronauts on deep space exploration missions. Compared with low-LET radiation, high-energy and high-LET radiation in space is more efficient in inducing clustered DNA damage with more serious biological c...

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Detalles Bibliográficos
Autores principales: Yan, Yujie, Zhang, Kunlan, Zhou, Guangming, Hu, Wentao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555309/
https://www.ncbi.nlm.nih.gov/pubmed/32917057
http://dx.doi.org/10.3390/ijms21186603
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author Yan, Yujie
Zhang, Kunlan
Zhou, Guangming
Hu, Wentao
author_facet Yan, Yujie
Zhang, Kunlan
Zhou, Guangming
Hu, Wentao
author_sort Yan, Yujie
collection PubMed
description High-energy and high-atom-number (HZE) space radiation poses an inevitable potential threat to astronauts on deep space exploration missions. Compared with low-LET radiation, high-energy and high-LET radiation in space is more efficient in inducing clustered DNA damage with more serious biological consequences, such as carcinogenesis, central nervous system injury and degenerative disease. Space radiation also causes epigenetic changes in addition to inducing damage at the DNA level. Considering the important roles of microRNAs in the regulation of biological responses of radiation, we systematically reviewed both expression profiling and functional studies relating to microRNAs responding to space radiation as well as to space compound environment. Finally, the directions for improvement of the research related to microRNAs responding to space radiation are proposed. A better understanding of the functions and underlying mechanisms of the microRNAs responding to space radiation is of significance to both space radiation risk assessment and therapy development for lesions caused by space radiation.
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spelling pubmed-75553092020-10-19 MicroRNAs Responding to Space Radiation Yan, Yujie Zhang, Kunlan Zhou, Guangming Hu, Wentao Int J Mol Sci Review High-energy and high-atom-number (HZE) space radiation poses an inevitable potential threat to astronauts on deep space exploration missions. Compared with low-LET radiation, high-energy and high-LET radiation in space is more efficient in inducing clustered DNA damage with more serious biological consequences, such as carcinogenesis, central nervous system injury and degenerative disease. Space radiation also causes epigenetic changes in addition to inducing damage at the DNA level. Considering the important roles of microRNAs in the regulation of biological responses of radiation, we systematically reviewed both expression profiling and functional studies relating to microRNAs responding to space radiation as well as to space compound environment. Finally, the directions for improvement of the research related to microRNAs responding to space radiation are proposed. A better understanding of the functions and underlying mechanisms of the microRNAs responding to space radiation is of significance to both space radiation risk assessment and therapy development for lesions caused by space radiation. MDPI 2020-09-09 /pmc/articles/PMC7555309/ /pubmed/32917057 http://dx.doi.org/10.3390/ijms21186603 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yan, Yujie
Zhang, Kunlan
Zhou, Guangming
Hu, Wentao
MicroRNAs Responding to Space Radiation
title MicroRNAs Responding to Space Radiation
title_full MicroRNAs Responding to Space Radiation
title_fullStr MicroRNAs Responding to Space Radiation
title_full_unstemmed MicroRNAs Responding to Space Radiation
title_short MicroRNAs Responding to Space Radiation
title_sort micrornas responding to space radiation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555309/
https://www.ncbi.nlm.nih.gov/pubmed/32917057
http://dx.doi.org/10.3390/ijms21186603
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