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Current Progress and Perspective: Clinical Imaging of Islet Transplantation

Islet transplantation has great potential as a cure for type 1 diabetes. At present; the lack of a clinically validated non-invasive imaging method to track islet grafts limits the success of this treatment. Some major clinical imaging modalities and various molecular probes, which have been studied...

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Autores principales: Richards, Taylor Marie, Sun, Aixia, Hayat, Hasaan, Robertson, Neil, Zhang, Zhaoda, Fan, Jinda, Wang, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555367/
https://www.ncbi.nlm.nih.gov/pubmed/32961769
http://dx.doi.org/10.3390/life10090213
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author Richards, Taylor Marie
Sun, Aixia
Hayat, Hasaan
Robertson, Neil
Zhang, Zhaoda
Fan, Jinda
Wang, Ping
author_facet Richards, Taylor Marie
Sun, Aixia
Hayat, Hasaan
Robertson, Neil
Zhang, Zhaoda
Fan, Jinda
Wang, Ping
author_sort Richards, Taylor Marie
collection PubMed
description Islet transplantation has great potential as a cure for type 1 diabetes. At present; the lack of a clinically validated non-invasive imaging method to track islet grafts limits the success of this treatment. Some major clinical imaging modalities and various molecular probes, which have been studied for non-invasive monitoring of transplanted islets, could potentially fulfill the goal of understanding pathophysiology of the functional status and viability of the islet grafts. In this current review, we summarize the recent clinical studies of a variety of imaging modalities and molecular probes for non-invasive imaging of transplanted beta cell mass. This review also includes discussions on in vivo detection of endogenous beta cell mass using clinical imaging modalities and various molecular probes, which will be useful for longitudinally detecting the status of islet transplantation in Type 1 diabetic patients. For the conclusion and perspectives, we highlight the applications of multimodality and novel imaging methods in islet transplantation.
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spelling pubmed-75553672020-10-19 Current Progress and Perspective: Clinical Imaging of Islet Transplantation Richards, Taylor Marie Sun, Aixia Hayat, Hasaan Robertson, Neil Zhang, Zhaoda Fan, Jinda Wang, Ping Life (Basel) Review Islet transplantation has great potential as a cure for type 1 diabetes. At present; the lack of a clinically validated non-invasive imaging method to track islet grafts limits the success of this treatment. Some major clinical imaging modalities and various molecular probes, which have been studied for non-invasive monitoring of transplanted islets, could potentially fulfill the goal of understanding pathophysiology of the functional status and viability of the islet grafts. In this current review, we summarize the recent clinical studies of a variety of imaging modalities and molecular probes for non-invasive imaging of transplanted beta cell mass. This review also includes discussions on in vivo detection of endogenous beta cell mass using clinical imaging modalities and various molecular probes, which will be useful for longitudinally detecting the status of islet transplantation in Type 1 diabetic patients. For the conclusion and perspectives, we highlight the applications of multimodality and novel imaging methods in islet transplantation. MDPI 2020-09-19 /pmc/articles/PMC7555367/ /pubmed/32961769 http://dx.doi.org/10.3390/life10090213 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Richards, Taylor Marie
Sun, Aixia
Hayat, Hasaan
Robertson, Neil
Zhang, Zhaoda
Fan, Jinda
Wang, Ping
Current Progress and Perspective: Clinical Imaging of Islet Transplantation
title Current Progress and Perspective: Clinical Imaging of Islet Transplantation
title_full Current Progress and Perspective: Clinical Imaging of Islet Transplantation
title_fullStr Current Progress and Perspective: Clinical Imaging of Islet Transplantation
title_full_unstemmed Current Progress and Perspective: Clinical Imaging of Islet Transplantation
title_short Current Progress and Perspective: Clinical Imaging of Islet Transplantation
title_sort current progress and perspective: clinical imaging of islet transplantation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555367/
https://www.ncbi.nlm.nih.gov/pubmed/32961769
http://dx.doi.org/10.3390/life10090213
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