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Current Progress and Perspective: Clinical Imaging of Islet Transplantation
Islet transplantation has great potential as a cure for type 1 diabetes. At present; the lack of a clinically validated non-invasive imaging method to track islet grafts limits the success of this treatment. Some major clinical imaging modalities and various molecular probes, which have been studied...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555367/ https://www.ncbi.nlm.nih.gov/pubmed/32961769 http://dx.doi.org/10.3390/life10090213 |
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author | Richards, Taylor Marie Sun, Aixia Hayat, Hasaan Robertson, Neil Zhang, Zhaoda Fan, Jinda Wang, Ping |
author_facet | Richards, Taylor Marie Sun, Aixia Hayat, Hasaan Robertson, Neil Zhang, Zhaoda Fan, Jinda Wang, Ping |
author_sort | Richards, Taylor Marie |
collection | PubMed |
description | Islet transplantation has great potential as a cure for type 1 diabetes. At present; the lack of a clinically validated non-invasive imaging method to track islet grafts limits the success of this treatment. Some major clinical imaging modalities and various molecular probes, which have been studied for non-invasive monitoring of transplanted islets, could potentially fulfill the goal of understanding pathophysiology of the functional status and viability of the islet grafts. In this current review, we summarize the recent clinical studies of a variety of imaging modalities and molecular probes for non-invasive imaging of transplanted beta cell mass. This review also includes discussions on in vivo detection of endogenous beta cell mass using clinical imaging modalities and various molecular probes, which will be useful for longitudinally detecting the status of islet transplantation in Type 1 diabetic patients. For the conclusion and perspectives, we highlight the applications of multimodality and novel imaging methods in islet transplantation. |
format | Online Article Text |
id | pubmed-7555367 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75553672020-10-19 Current Progress and Perspective: Clinical Imaging of Islet Transplantation Richards, Taylor Marie Sun, Aixia Hayat, Hasaan Robertson, Neil Zhang, Zhaoda Fan, Jinda Wang, Ping Life (Basel) Review Islet transplantation has great potential as a cure for type 1 diabetes. At present; the lack of a clinically validated non-invasive imaging method to track islet grafts limits the success of this treatment. Some major clinical imaging modalities and various molecular probes, which have been studied for non-invasive monitoring of transplanted islets, could potentially fulfill the goal of understanding pathophysiology of the functional status and viability of the islet grafts. In this current review, we summarize the recent clinical studies of a variety of imaging modalities and molecular probes for non-invasive imaging of transplanted beta cell mass. This review also includes discussions on in vivo detection of endogenous beta cell mass using clinical imaging modalities and various molecular probes, which will be useful for longitudinally detecting the status of islet transplantation in Type 1 diabetic patients. For the conclusion and perspectives, we highlight the applications of multimodality and novel imaging methods in islet transplantation. MDPI 2020-09-19 /pmc/articles/PMC7555367/ /pubmed/32961769 http://dx.doi.org/10.3390/life10090213 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Richards, Taylor Marie Sun, Aixia Hayat, Hasaan Robertson, Neil Zhang, Zhaoda Fan, Jinda Wang, Ping Current Progress and Perspective: Clinical Imaging of Islet Transplantation |
title | Current Progress and Perspective: Clinical Imaging of Islet Transplantation |
title_full | Current Progress and Perspective: Clinical Imaging of Islet Transplantation |
title_fullStr | Current Progress and Perspective: Clinical Imaging of Islet Transplantation |
title_full_unstemmed | Current Progress and Perspective: Clinical Imaging of Islet Transplantation |
title_short | Current Progress and Perspective: Clinical Imaging of Islet Transplantation |
title_sort | current progress and perspective: clinical imaging of islet transplantation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555367/ https://www.ncbi.nlm.nih.gov/pubmed/32961769 http://dx.doi.org/10.3390/life10090213 |
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