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Dim Light at Night Disturbs Molecular Pathways of Lipid Metabolism

Dim light at night (dLAN) is associated with metabolic risk but the specific effects on lipid metabolism have only been evaluated to a limited extent. Therefore, to explore whether dLAN can compromise lipid metabolic homeostasis in healthy individuals, we exposed Wistar rats to dLAN (~2 lx) for 2 an...

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Autores principales: Okuliarova, Monika, Rumanova, Valentina Sophia, Stebelova, Katarina, Zeman, Michal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555372/
https://www.ncbi.nlm.nih.gov/pubmed/32967195
http://dx.doi.org/10.3390/ijms21186919
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author Okuliarova, Monika
Rumanova, Valentina Sophia
Stebelova, Katarina
Zeman, Michal
author_facet Okuliarova, Monika
Rumanova, Valentina Sophia
Stebelova, Katarina
Zeman, Michal
author_sort Okuliarova, Monika
collection PubMed
description Dim light at night (dLAN) is associated with metabolic risk but the specific effects on lipid metabolism have only been evaluated to a limited extent. Therefore, to explore whether dLAN can compromise lipid metabolic homeostasis in healthy individuals, we exposed Wistar rats to dLAN (~2 lx) for 2 and 5 weeks and analyzed the main lipogenic pathways in the liver and epididymal fat pad, including the control mechanisms at the hormonal and molecular level. We found that dLAN promoted hepatic triacylglycerol accumulation, upregulated hepatic genes involved in de novo synthesis of fatty acids, and elevated glucose and fatty acid uptake. These observations were paralleled with suppressed fatty acid synthesis in the adipose tissue and altered plasma adipokine levels, indicating disturbed adipocyte metabolic function with a potential negative impact on liver metabolism. Moreover, dLAN-exposed rats displayed an elevated expression of two peroxisome proliferator-activated receptor family members (Pparα and Pparγ) in the liver and adipose tissue, suggesting the deregulation of important metabolic transcription factors. Together, our results demonstrate that an impaired balance of lipid biosynthetic pathways caused by dLAN can increase lipid storage in the liver, thereby accounting for a potential linking mechanism between dLAN and metabolic diseases.
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spelling pubmed-75553722020-10-19 Dim Light at Night Disturbs Molecular Pathways of Lipid Metabolism Okuliarova, Monika Rumanova, Valentina Sophia Stebelova, Katarina Zeman, Michal Int J Mol Sci Article Dim light at night (dLAN) is associated with metabolic risk but the specific effects on lipid metabolism have only been evaluated to a limited extent. Therefore, to explore whether dLAN can compromise lipid metabolic homeostasis in healthy individuals, we exposed Wistar rats to dLAN (~2 lx) for 2 and 5 weeks and analyzed the main lipogenic pathways in the liver and epididymal fat pad, including the control mechanisms at the hormonal and molecular level. We found that dLAN promoted hepatic triacylglycerol accumulation, upregulated hepatic genes involved in de novo synthesis of fatty acids, and elevated glucose and fatty acid uptake. These observations were paralleled with suppressed fatty acid synthesis in the adipose tissue and altered plasma adipokine levels, indicating disturbed adipocyte metabolic function with a potential negative impact on liver metabolism. Moreover, dLAN-exposed rats displayed an elevated expression of two peroxisome proliferator-activated receptor family members (Pparα and Pparγ) in the liver and adipose tissue, suggesting the deregulation of important metabolic transcription factors. Together, our results demonstrate that an impaired balance of lipid biosynthetic pathways caused by dLAN can increase lipid storage in the liver, thereby accounting for a potential linking mechanism between dLAN and metabolic diseases. MDPI 2020-09-21 /pmc/articles/PMC7555372/ /pubmed/32967195 http://dx.doi.org/10.3390/ijms21186919 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Okuliarova, Monika
Rumanova, Valentina Sophia
Stebelova, Katarina
Zeman, Michal
Dim Light at Night Disturbs Molecular Pathways of Lipid Metabolism
title Dim Light at Night Disturbs Molecular Pathways of Lipid Metabolism
title_full Dim Light at Night Disturbs Molecular Pathways of Lipid Metabolism
title_fullStr Dim Light at Night Disturbs Molecular Pathways of Lipid Metabolism
title_full_unstemmed Dim Light at Night Disturbs Molecular Pathways of Lipid Metabolism
title_short Dim Light at Night Disturbs Molecular Pathways of Lipid Metabolism
title_sort dim light at night disturbs molecular pathways of lipid metabolism
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555372/
https://www.ncbi.nlm.nih.gov/pubmed/32967195
http://dx.doi.org/10.3390/ijms21186919
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