Cargando…

Influence of the Core Formulation on Features and Drug Delivery Ability of Carbamate-Based Nanogels

In the last years, nanogels have emerged as one of the most promising classes of novel drug delivery vehicles since they can be employed in multiple fields, such as various therapeutics or diagnostics, and with different classes of compounds and active molecules. Their features, such as a high volum...

Descripción completa

Detalles Bibliográficos
Autores principales: Pinelli, Filippo, Pizzetti, Fabio, Ortolà, Óscar Fullana, Marchetti, Alessandro, Rossetti, Arianna, Sacchetti, Alessandro, Rossi, Filippo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555386/
https://www.ncbi.nlm.nih.gov/pubmed/32927733
http://dx.doi.org/10.3390/ijms21186621
_version_ 1783593995882987520
author Pinelli, Filippo
Pizzetti, Fabio
Ortolà, Óscar Fullana
Marchetti, Alessandro
Rossetti, Arianna
Sacchetti, Alessandro
Rossi, Filippo
author_facet Pinelli, Filippo
Pizzetti, Fabio
Ortolà, Óscar Fullana
Marchetti, Alessandro
Rossetti, Arianna
Sacchetti, Alessandro
Rossi, Filippo
author_sort Pinelli, Filippo
collection PubMed
description In the last years, nanogels have emerged as one of the most promising classes of novel drug delivery vehicles since they can be employed in multiple fields, such as various therapeutics or diagnostics, and with different classes of compounds and active molecules. Their features, such as a high volume to surface ratio, excellent drug loading and release ability, as well as biocompatibility and tunable behavior, are unique, and, nowadays, great efforts are made to develop new formulations that can be employed in a wider range of applications. Polyethylene glycol (PEG)-polyethylenimine (PEI) nanogels probably represent the baseline of this class of biomaterials and they are still largely employed and studied. In any way, the possibility to exploit new core formulations for nanogels is certainly very interesting in order to understand the influence of different polymer chains on the final properties of the system. In this research, we explore and make a comparison between PEG-PEI nanogels and two other different formulations: pluronic F127-PEI nanogels and PEG-Jeffamine nanogels. We propose nanogels synthesis methods, their chemical and physical characterization, as well as their stability analysis, and we focus on the different drug delivery ability that these structures exhibit working with different typologies of drug mimetics.
format Online
Article
Text
id pubmed-7555386
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-75553862020-10-19 Influence of the Core Formulation on Features and Drug Delivery Ability of Carbamate-Based Nanogels Pinelli, Filippo Pizzetti, Fabio Ortolà, Óscar Fullana Marchetti, Alessandro Rossetti, Arianna Sacchetti, Alessandro Rossi, Filippo Int J Mol Sci Article In the last years, nanogels have emerged as one of the most promising classes of novel drug delivery vehicles since they can be employed in multiple fields, such as various therapeutics or diagnostics, and with different classes of compounds and active molecules. Their features, such as a high volume to surface ratio, excellent drug loading and release ability, as well as biocompatibility and tunable behavior, are unique, and, nowadays, great efforts are made to develop new formulations that can be employed in a wider range of applications. Polyethylene glycol (PEG)-polyethylenimine (PEI) nanogels probably represent the baseline of this class of biomaterials and they are still largely employed and studied. In any way, the possibility to exploit new core formulations for nanogels is certainly very interesting in order to understand the influence of different polymer chains on the final properties of the system. In this research, we explore and make a comparison between PEG-PEI nanogels and two other different formulations: pluronic F127-PEI nanogels and PEG-Jeffamine nanogels. We propose nanogels synthesis methods, their chemical and physical characterization, as well as their stability analysis, and we focus on the different drug delivery ability that these structures exhibit working with different typologies of drug mimetics. MDPI 2020-09-10 /pmc/articles/PMC7555386/ /pubmed/32927733 http://dx.doi.org/10.3390/ijms21186621 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pinelli, Filippo
Pizzetti, Fabio
Ortolà, Óscar Fullana
Marchetti, Alessandro
Rossetti, Arianna
Sacchetti, Alessandro
Rossi, Filippo
Influence of the Core Formulation on Features and Drug Delivery Ability of Carbamate-Based Nanogels
title Influence of the Core Formulation on Features and Drug Delivery Ability of Carbamate-Based Nanogels
title_full Influence of the Core Formulation on Features and Drug Delivery Ability of Carbamate-Based Nanogels
title_fullStr Influence of the Core Formulation on Features and Drug Delivery Ability of Carbamate-Based Nanogels
title_full_unstemmed Influence of the Core Formulation on Features and Drug Delivery Ability of Carbamate-Based Nanogels
title_short Influence of the Core Formulation on Features and Drug Delivery Ability of Carbamate-Based Nanogels
title_sort influence of the core formulation on features and drug delivery ability of carbamate-based nanogels
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555386/
https://www.ncbi.nlm.nih.gov/pubmed/32927733
http://dx.doi.org/10.3390/ijms21186621
work_keys_str_mv AT pinellifilippo influenceofthecoreformulationonfeaturesanddrugdeliveryabilityofcarbamatebasednanogels
AT pizzettifabio influenceofthecoreformulationonfeaturesanddrugdeliveryabilityofcarbamatebasednanogels
AT ortolaoscarfullana influenceofthecoreformulationonfeaturesanddrugdeliveryabilityofcarbamatebasednanogels
AT marchettialessandro influenceofthecoreformulationonfeaturesanddrugdeliveryabilityofcarbamatebasednanogels
AT rossettiarianna influenceofthecoreformulationonfeaturesanddrugdeliveryabilityofcarbamatebasednanogels
AT sacchettialessandro influenceofthecoreformulationonfeaturesanddrugdeliveryabilityofcarbamatebasednanogels
AT rossifilippo influenceofthecoreformulationonfeaturesanddrugdeliveryabilityofcarbamatebasednanogels