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Influence of the Core Formulation on Features and Drug Delivery Ability of Carbamate-Based Nanogels
In the last years, nanogels have emerged as one of the most promising classes of novel drug delivery vehicles since they can be employed in multiple fields, such as various therapeutics or diagnostics, and with different classes of compounds and active molecules. Their features, such as a high volum...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555386/ https://www.ncbi.nlm.nih.gov/pubmed/32927733 http://dx.doi.org/10.3390/ijms21186621 |
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author | Pinelli, Filippo Pizzetti, Fabio Ortolà, Óscar Fullana Marchetti, Alessandro Rossetti, Arianna Sacchetti, Alessandro Rossi, Filippo |
author_facet | Pinelli, Filippo Pizzetti, Fabio Ortolà, Óscar Fullana Marchetti, Alessandro Rossetti, Arianna Sacchetti, Alessandro Rossi, Filippo |
author_sort | Pinelli, Filippo |
collection | PubMed |
description | In the last years, nanogels have emerged as one of the most promising classes of novel drug delivery vehicles since they can be employed in multiple fields, such as various therapeutics or diagnostics, and with different classes of compounds and active molecules. Their features, such as a high volume to surface ratio, excellent drug loading and release ability, as well as biocompatibility and tunable behavior, are unique, and, nowadays, great efforts are made to develop new formulations that can be employed in a wider range of applications. Polyethylene glycol (PEG)-polyethylenimine (PEI) nanogels probably represent the baseline of this class of biomaterials and they are still largely employed and studied. In any way, the possibility to exploit new core formulations for nanogels is certainly very interesting in order to understand the influence of different polymer chains on the final properties of the system. In this research, we explore and make a comparison between PEG-PEI nanogels and two other different formulations: pluronic F127-PEI nanogels and PEG-Jeffamine nanogels. We propose nanogels synthesis methods, their chemical and physical characterization, as well as their stability analysis, and we focus on the different drug delivery ability that these structures exhibit working with different typologies of drug mimetics. |
format | Online Article Text |
id | pubmed-7555386 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75553862020-10-19 Influence of the Core Formulation on Features and Drug Delivery Ability of Carbamate-Based Nanogels Pinelli, Filippo Pizzetti, Fabio Ortolà, Óscar Fullana Marchetti, Alessandro Rossetti, Arianna Sacchetti, Alessandro Rossi, Filippo Int J Mol Sci Article In the last years, nanogels have emerged as one of the most promising classes of novel drug delivery vehicles since they can be employed in multiple fields, such as various therapeutics or diagnostics, and with different classes of compounds and active molecules. Their features, such as a high volume to surface ratio, excellent drug loading and release ability, as well as biocompatibility and tunable behavior, are unique, and, nowadays, great efforts are made to develop new formulations that can be employed in a wider range of applications. Polyethylene glycol (PEG)-polyethylenimine (PEI) nanogels probably represent the baseline of this class of biomaterials and they are still largely employed and studied. In any way, the possibility to exploit new core formulations for nanogels is certainly very interesting in order to understand the influence of different polymer chains on the final properties of the system. In this research, we explore and make a comparison between PEG-PEI nanogels and two other different formulations: pluronic F127-PEI nanogels and PEG-Jeffamine nanogels. We propose nanogels synthesis methods, their chemical and physical characterization, as well as their stability analysis, and we focus on the different drug delivery ability that these structures exhibit working with different typologies of drug mimetics. MDPI 2020-09-10 /pmc/articles/PMC7555386/ /pubmed/32927733 http://dx.doi.org/10.3390/ijms21186621 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Pinelli, Filippo Pizzetti, Fabio Ortolà, Óscar Fullana Marchetti, Alessandro Rossetti, Arianna Sacchetti, Alessandro Rossi, Filippo Influence of the Core Formulation on Features and Drug Delivery Ability of Carbamate-Based Nanogels |
title | Influence of the Core Formulation on Features and Drug Delivery Ability of Carbamate-Based Nanogels |
title_full | Influence of the Core Formulation on Features and Drug Delivery Ability of Carbamate-Based Nanogels |
title_fullStr | Influence of the Core Formulation on Features and Drug Delivery Ability of Carbamate-Based Nanogels |
title_full_unstemmed | Influence of the Core Formulation on Features and Drug Delivery Ability of Carbamate-Based Nanogels |
title_short | Influence of the Core Formulation on Features and Drug Delivery Ability of Carbamate-Based Nanogels |
title_sort | influence of the core formulation on features and drug delivery ability of carbamate-based nanogels |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555386/ https://www.ncbi.nlm.nih.gov/pubmed/32927733 http://dx.doi.org/10.3390/ijms21186621 |
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